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Martijn van de Bunt


Novo Nordisk Postdoctoral Research Fellow (2014-2017)

  • Project: Insights into type 2 diabetes pathogenesis through transcriptomic and functional analysis of the developing human islet'

Biography

Martijn was awarded a Novo Nordisk Postdoctoral Research Fellowship, working with Professors Mark McCarthy and Anna Gloyn at the Oxford Centre for Diabetes, Endocrinology & Metabolism and the Wellcome Trust Centre for Human Genetics. His research aimed to improve understanding of islet biology and pathophysiology through the integrative analysis of large genomic datasets on key type 2 diabetes tissues with findings from human genetics. Martijn’s work led to significant advances in understanding of type 2 diabetes and glycaemic trait genome-wide association loci – for example identifying a novel regulator of insulin secretion, ZMIZ1. Martijn was awarded a prestigious American Society for Human Genetics (ASHG) Charles J Epstein Trainee Award for Excellence in Human Genetics Research.

Following his Novo Nordisk fellowship at the University of Oxford, Martijn moved to Novo Nordisk, Copenhagen, in May 2017. He joined the Global Research Unit as an Informatics Specialist to provide bioinformatics expertise for target discovery and validation efforts and to develop broader new initiatives within that realm.

selected Publications

An alternative effector gene at the type 2 diabetes-associated TCF7L2 locus?
van de Bunt M, (2016), Diabetologia

Insights into islet development and biology through characterization of a human iPSC-derived endocrine pancreas model
van de Bunt M, Lako M, et al, (2016), Islets

Transcript expression data from human islets links regulatory signals from genome-wide association studies for type 2 diabetes and glycemic traits to their downstream effectors
van de Bunt M, Manning-Fox JE, et al, (2015), PLoS Genet

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