Katharine Owen
Associate Professor of Diabetes
- NIHR Clinician Scientist
- Honorary Consultant Physician
Diabetes arising in young adults has a wide range of underlying aetiologies. This includes genetic causes of beta-cell dysfunction (Maturity-onset diabetes of the young, MODY). We are investigating the characteristics of different subtypes of MODY and how to identify them from those with commoner causes of diabetes. Our research programme aims to implement systematic diagnostics for aetiology of diabetes into routine clinical care. At the moment we are investigating whether there are specific non-genetic biomarkers for MODY subtypes and have recently discovered that low levels of highly-sensitive C-reactive protein are a marker for HNF1A mutations.
Recent publications
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Traditional clinical criteria outperform high-sensitivity C-reactive protein for the screening of hepatic nuclear factor 1 alpha maturity-onset diabetes of the young among young Asians with diabetes.
Journal article
Rama Chandran S. et al, (2018), Ther Adv Endocrinol Metab, 9, 271 - 282
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Maturity onset diabetes of the young due to HNF1A variants in Croatia.
Journal article
Pavić T. et al, (2018), Biochem Med (Zagreb), 28
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Monogenic diabetes in adults: what are the new developments?
Journal article
Owen KR., (2018), Curr Opin Genet Dev, 50, 103 - 110
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Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.
Journal article
Turcot V. et al, (2018), Nat Genet, 50, 765 - 766
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Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.
Journal article
Turcot V. et al, (2018), Nat Genet, 50, 766 - 767