Katharine Owen

• A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk.

  Journal article

  Manning A. et al, (2017), Diabetes, 66, 2019 - 2032

• An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans.

  Journal article

  Scott RA. et al, (2017), Diabetes

• Treatment and outcomes of HNF1A-MODY patients from a specialist monogenic diabetes clinic

  Journal article

  Juszczak A. et al, (2017), DIABETIC MEDICINE, 34, 156 - 156

• Very long duration of optimal diabetes control on Sulphonylurea agents in HNF1A-MODY

  Journal article

  Juszczak A. et al, (2017), DIABETIC MEDICINE, 34, 101 - 101

• Management of hypoglycaemia in people with Type 1 diabetes and referral for transplantation among UK diabetologists: results from a national survey

  Journal article

  Ballav C. et al, (2017), DIABETIC MEDICINE, 34, 114 - 114

• When to consider a diagnosis of MODY at the presentation of diabetes: aetiology matters for correct management.

  Journal article

  Juszczak A. et al, (2016), Br J Gen Pract, 66, e457 - e459

• Treating young adults with type 2 diabetes or monogenic diabetes.

  Journal article

  Owen KR., (2016), Best Pract Res Clin Endocrinol Metab, 30, 455 - 467

• Using stratified medicine in diabetes

  Journal article

  Owen KR., (2016), Biochemist, 38, 19 - 21

• Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.

  Journal article

  Gaulton KJ. et al, (2015), Nat Genet, 47, 1415 - 1425

• miR-375 gene dosage in pancreatic β-cells: implications for regulation of β-cell mass and biomarker development

  Journal article

  Latreille M. et al, (2015), Journal of Molecular Medicine, 93, 1159 - 1169

• miR-375 gene dosage in pancreatic β-cells: implications for regulation of β-cell mass and biomarker development.

  Journal article

  Latreille M. et al, (2015), J Mol Med (Berl), 93, 1159 - 1169

• Monogenic diabetes: the treatment options.

  Journal article

  Owen KR., (2015), Diabet Med, 32, 429 - 430

• Considering monogenic diabetes at first presentation of diabetes establishes optimal treatment from diagnosis in young adults with maturity onset diabetes of the young

  Journal article

  Juszczak A. et al, (2015), DIABETIC MEDICINE, 32, 14 - 14

• Using gamification to encourage blood glucose testing in children with Type 1 diabetes

  Journal article

  Sheehy S. et al, (2015), DIABETIC MEDICINE, 32, 136 - 137

• Using genomic information to differentiate aetiology in young adult onset diabetes

  Journal article

  Kavvoura FK. et al, (2015), DIABETIC MEDICINE, 32, 18 - 18

• Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus.

  Journal article

  Mahajan A. et al, (2015), PLoS Genet, 11

• Glucokinase MODY and implications for treatment goals of common forms of diabetes.

  Journal article

  Ajjan RA. and Owen KR., (2014), Curr Diab Rep, 14

• Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes.

  Journal article

  Ng MC. et al, (2014), PLoS Genet, 10

• Reclassification of diabetes etiology in a family with multiple diabetes phenotypes.

  Journal article

  Kavvoura FK. et al, (2014), J Clin Endocrinol Metab, 99, E1067 - E1071

• Diagnostic and therapeutic challenge in a patient with mixed phenotype diabetes

  Journal article

  Juszczak A. et al, (2014), DIABETIC MEDICINE, 31, 20 - 21

• Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.

  Journal article

  DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium None. et al, (2014), Nat Genet, 46, 234 - 244

• HNF1A-MODY is associated with an intact CRP response during human endotoxaemia

  Journal article

  Mughal SA. et al, (2014), DIABETIC MEDICINE, 31, 54 - 55

• Reclassification of diabetes etiology in a family with multiple diabetes phenotypes

  Conference paper

  Kavvoura FK. et al, (2014), Journal of Clinical Endocrinology and Metabolism, 99

• Type 2 diabetes in the young: Why we should worry

  Journal article

  Thanabalasingham G. and Owen KR., (2014), Practical Diabetes, 31, 225 - 227

• Translating advances in our understanding of the genetics of diabetes into the clinic

  Journal article

  Gardner DS. et al, (2014), Frontiers in Diabetes, 23, 173 - 186

• Monogenic diabetes

  Journal article

  Kavvoura FK. and Owen KR., (2014), Medicine (United Kingdom), 42, 692 - 697

• Self-management of diabetes in children and young adults using technology and smartphone applications.

  Journal article

  Sheehy S. et al, (2014), Curr Diabetes Rev, 10, 298 - 301

• Comparability of high-sensitivity CRP methods to detect maturity-onset diabetes of the young due to HNF1A mutations.

  Journal article

  Shah N. et al, (2014), Br J Biomed Sci, 71, 84 - 85

• PAX6 mutation in association with ptosis, cataract, iris hypoplasia, corneal opacification and diabetes: A new variant of familial aniridia?

  Journal article

  Peter NM. et al, (2013), Clinical and Experimental Ophthalmology, 41, 835 - 841

• PAX6 mutation in association with ptosis, cataract, iris hypoplasia, corneal opacification and diabetes: a new variant of familial aniridia?

  Journal article

  Peter NM. et al, (2013), Clin Exp Ophthalmol, 41, 835 - 841

• Cystatin C is not a good candidate biomarker for HNF1A-MODY.

  Journal article

  Nowak N. et al, (2013), Acta Diabetol, 50, 815 - 820

• No attenuation of CRP response to acute inflammation is seen in HNF1A-MODY

  Conference paper

  Owen KR. et al, (2013), DIABETOLOGIA, 56, S151 - S152

• Atypical phenotype associated with reported GCK exon 10 deletions: Clinical judgement is needed alongside appropriate genetic investigations.

  Journal article

  Thanabalasingham G. et al, (2013), Diabet Med, 30, e233 - e238

• Monogenic diabetes: Old and new approaches to diagnosis

  Journal article

  Owen KR., (2013), Clinical Medicine, Journal of the Royal College of Physicians of London, 13, 278 - 281

• Monogenic diabetes: old and new approaches to diagnosis.

  Journal article

  Owen KR., (2013), Clin Med (Lond), 13, 278 - 281

• Mutations in HNF1A result in marked alterations of plasma glycan profile.

  Journal article

  Thanabalasingham G. et al, (2013), Diabetes, 62, 1329 - 1337

• RD Lawrence lecture 2012: assessing aetiology in diabetes: how C-peptide, CRP and fucosylation came to the party!

  Journal article

  Owen KR., (2013), Diabet Med, 30, 260 - 266

• One is never enough: a case report of three different diabetes phenotypes in a single family

  Journal article

  Kavvoura FK. et al, (2013), DIABETIC MEDICINE, 30, 1 - 1

• Simultaneous pancreas and kidney transplantation (SPK) should be indicated for patients with maturity-onset diabetes of the young (MODY) and end-stage nephropathy

  Journal article

  Eininger AK. et al, (2013), DIABETIC MEDICINE, 30, 92 - 93

• Evaluation of high sensitivity C-reactive protein as a screening tool for detecting young South Asians with maturity-onset diabetes of the young due to HNF1A mutations

  Journal article

  Mughal SA. et al, (2013), DIABETIC MEDICINE, 30, 61 - 61

• Use of high sensitivity C-reactive protein and DG9-glycan index for differential diagnosis of maturity-onset diabetes of the young due to HNF1A mutations in young adults

  Journal article

  Mughal SA. et al, (2013), DIABETIC MEDICINE, 30, 26 - 26

• Assessment of the pathogenicity of the previously reported D526N Hepatocyte Nuclear factor-1 alpha (HNF1A) variant using a combined genetic, in silico and functional approach

  Journal article

  Hassanali N. et al, (2013), DIABETIC MEDICINE, 30, 61 - 61

• Apolipoprotein M can discriminate HNF1A-MODY from Type 1 diabetes.

  Journal article

  Mughal SA. et al, (2013), Diabet Med, 30, 246 - 250

• Cystatin C is not a good candidate biomarker for HNF1A-MODY

  Journal article

  Nowak N. et al, (2013), Acta Diabetologica, 50, 815 - 820

• Maturity onset diabetes of the young: clinical characteristics, diagnosis and management.

  Journal article

  Kavvoura FK. and Owen KR., (2012), Pediatr Endocrinol Rev, 10, 234 - 242

• Integration of biomarkers and clinical characteristics provides the best method for identifying patients with MODY

  Journal article

  Shields BM. et al, (2012), DIABETOLOGIA, 55, S144 - S144

• Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.

  Journal article

  Morris AP. et al, (2012), Nat Genet, 44, 981 - 990

• Systematic assessment of etiology in adults with a clinical diagnosis of young-onset type 2 diabetes is a successful strategy for identifying maturity-onset diabetes of the young.

  Journal article

  Thanabalasingham G. et al, (2012), Diabetes Care, 35, 1206 - 1212

• Lipoprotein composition in HNF1A-MODY: differentiating between HNF1A-MODY and type 2 diabetes.

  Journal article

  McDonald TJ. et al, (2012), Clin Chim Acta, 413, 927 - 932

• Metabolic profiling in Maturity-onset diabetes of the young (MODY) and young onset type 2 diabetes fails to detect robust urinary biomarkers.

  Journal article

  Gloyn AL. et al, (2012), PLoS One, 7

• Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.

  Journal article

  Dastani Z. et al, (2012), PLoS Genet, 8

• Response to Comment on: McDonald et al. High-Sensitivity CRP Discriminates HNF1A-MODY From Other Subtypes of Diabetes. Diabetes Care 2011;34:1860-1862.

  Journal article

  McDonald TJ. et al, (2011), Diabetes Care, 34

• Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1.

  Journal article

  Bown MJ. et al, (2011), Am J Hum Genet, 89, 619 - 627

• A large multi-centre European study validates high-sensitivity C-reactive protein (hsCRP) as a clinical biomarker for the diagnosis of diabetes subtypes

  Journal article

  Thanabalasingham G. et al, (2011), Diabetologia, 54, 2801 - 2810

• A large multi-centre European study validates high-sensitivity C-reactive protein (hsCRP) as a clinical biomarker for the diagnosis of diabetes subtypes.

  Journal article

  Thanabalasingham G. et al, (2011), Diabetologia, 54, 2801 - 2810

• Diagnosis and management of maturity onset diabetes of the young (MODY).

  Journal article

  Thanabalasingham G. and Owen KR., (2011), BMJ, 343

• Diagnosis and management of maturity onset diabetes of the young (MODY)

  Journal article

  Thanabalasingham G. and Owen KR., (2011), BRITISH MEDICAL JOURNAL, 343

• Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.

  Journal article

  Strawbridge RJ. et al, (2011), Diabetes, 60, 2624 - 2634

• Identification and assessment of glycan profiles as a biomarker for maturity onset diabetes of the young (MODY) due to hepatocyte nuclear factor 1 alpha (HNF1A) mutations

  Conference paper

  Gloyn AL. et al, (2011), DIABETOLOGIA, 54, S72 - S73

• High-sensitivity CRP discriminates HNF1A-MODY from other subtypes of diabetes.

  Journal article

  McDonald TJ. et al, (2011), Diabetes care, 34, 1860 - 1862

• High-sensitivity CRP discriminates HNF1A-MODY from other subtypes of diabetes.

  Journal article

  McDonald TJ. et al, (2011), Diabetes Care, 34, 1860 - 1862

• Maturity onset diabetes of the young is characterised by less thrombotic fibrin network structure compared with phenotypically similar type 2 diabetes subjects

  Journal article

  Ajjan RA. et al, (2011), JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 9, 140 - 140

• Investigating the role of the recently described Type 2 diabetes associated gene CDKN2A (p16) on pancreatic islet function using a human model of CDKN2A haploinsufficiency (vol 28, pg 53, 2011)

  Journal article

  Pal A. et al, (2011), DIABETIC MEDICINE, 28, 881 - 881

• Sequencing PDX1 (insulin promoter factor 1) in 1788 UK individuals found 5% had a low frequency coding variant, but these variants are not associated with Type 2 diabetes.

  Journal article

  Edghill EL. et al, (2011), Diabet Med, 28, 681 - 684

• Prevalence of monogenic diabetes in young adults: A community-based, cross-sectional study in Oxfordshire, UK

  Journal article

  Kropff J. et al, (2011), Diabetologia, 54, 1261 - 1263

• Prevalence of monogenic diabetes in young adults: a community-based, cross-sectional study in Oxfordshire, UK.

  Journal article

  Kropff J. et al, (2011), Diabetologia, 54, 1261 - 1263

• Diagnosis and management of maturity onset diabetes of the young (MODY).

  Journal article

  Thanabalasingham G. and Owen KR., (2011), BMJ (Clinical research ed.), 343

• Role of low frequency variants in HNF1A exons 8-10 encoding hepatocyte nuclear factor-1 alpha isoform A to susceptibility to Type 2 diabetes

  Journal article

  Jafar-Mohammadi B. et al, (2010), IRISH JOURNAL OF MEDICAL SCIENCE, 179, 538 - 538

• Differences in thrombotic and inflammatory markers comparing subjects with maturity onset diabetes of the young and type 2 diabetes

  Conference paper

  Bottomley MJ. et al, (2010), DIABETOLOGIA, 53, S116 - S116

• Extending criteria for genetic testing increases diagnosis of maturity-onset diabetes of the young

  Conference paper

  Thanabalasingham G. et al, (2010), DIABETOLOGIA, 53, S63 - S63

• Assessment of high-sensitivity C-reactive protein levels as diagnostic discriminator of maturity-onset diabetes of the young due to HNF1A mutations.

  Journal article

  Owen KR. et al, (2010), Diabetes Care, 33, 1919 - 1924

• Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

  Journal article

  Voight BF. et al, (2010), Nature Genetics, 42, 579 - 589

• Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes.

  Journal article

  Perry JR. et al, (2010), Hum Mol Genet, 19, 535 - 544

• Evaluation of serum 1,5 anhydroglucitol levels as a clinical test to differentiate subtypes of diabetes.

  Journal article

  Pal A. et al, (2010), Diabetes Care, 33, 252 - 257

• Parental origin of sequence variants associated with complex diseases

  Journal article

  Kong A. et al, (2009), Nature, 462, 868 - 874

• The clinical application of non-genetic biomarkers for differential diagnosis of monogenic diabetes.

  Journal article

  Owen KR. et al, (2009), Diabetes Res Clin Pract, 86 Suppl 1, S15 - S21

• Type 1 and type 2 diabetes-chalk and cheese?

  Journal article

  Owen KR. and McCarthy MI., (2009), Diabetologia, 52, 1983 - 1986

• The use of 1,5 anhydroglucitol level as a clinical test to differentiate subtypes of diabetes

  Conference paper

  Owen KR. et al, (2009), DIABETOLOGIA, 52, S105 - S105

• Low frequency variants in the exons only encoding isoform A of HNF1A do not contribute to susceptibility to type 2 diabetes.

  Journal article

  Jafar-Mohammadi B. et al, (2009), PLoS One, 4

• Keeping diabetes in the family: Lessons from a family with HNF-1α MODY

  Journal article

  Selwood MP. and Owen KR., (2008), European Diabetes Nursing, 5, 70 - 74

• Common variants near MC4R are associated with fat mass, weight and risk of obesity.

  Journal article

  Loos RJ. et al, (2008), Nat Genet, 40, 768 - 775

• Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.

  Journal article

  Zeggini E. et al, (2008), Nat Genet, 40, 638 - 645

• Comparison of prioritisation strategies for selecting subjects with apparent type 1 diabetes for MODY gene sequencing

  Conference paper

  Owen KR. et al, (2007), DIABETOLOGIA, 50, S124 - S124

• Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.

  Journal article

  Zeggini E. et al, (2007), Science, 316, 1336 - 1341

• Genetics of type 2 diabetes.

  Journal article

  Owen KR. and McCarthy MI., (2007), Curr Opin Genet Dev, 17, 239 - 244

• A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity.

  Journal article

  Frayling TM. et al, (2007), Science, 316, 889 - 894

• C-peptide measurement provides evidence for misdiagnosis in clinically classified Type 1 diabetes

  Journal article

  Selwood MP. et al, (2007), DIABETIC MEDICINE, 24, 6 - 6

• Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes: association analyses in 9,518 subjects.

  Journal article

  Owen KR. et al, (2007), Diabetes, 56, 879 - 883

• An association analysis of the HLA gene region in latent autoimmune diabetes in adults.

  Journal article

  Desai M. et al, (2007), Diabetologia, 50, 68 - 73

• Combining information from common type 2 diabetes risk polymorphisms improves disease prediction.

  Journal article

  Weedon MN. et al, (2006), PLoS Med, 3

• Common variation in the LMNA gene increases susceptibility to type 2 diabetes

  Conference paper

  Owen KR. et al, (2006), DIABETOLOGIA, 49, 206 - 206

• Syndromic obesity and diabetes: changes in body composition with age and mutation analysis of ALMS1 in 12 United Kingdom kindreds with Alstrom syndrome.

  Journal article

  Minton JA. et al, (2006), J Clin Endocrinol Metab, 91, 3110 - 3116

• Assessment of the role of common genetic variation in the transient neonatal diabetes mellitus (TNDM) region in type 2 diabetes: a comparative genomic and tagging single nucleotide polymorphism approach.

  Journal article

  Gloyn AL. et al, (2006), Diabetes, 55, 2272 - 2276

• The variable number of tandem repeats upstream of the insulin gene is a susceptibility locus for latent autoimmune diabetes in adults.

  Journal article

  Desai M. et al, (2006), Diabetes, 55, 1890 - 1894

• Examining the relationships between the Pro12Ala variant in PPARG and Type 2 diabetes-related traits in UK samples.

  Journal article

  Zeggini E. et al, (2005), Diabet Med, 22, 1696 - 1700

• Large-scale studies of the association between variation at the TNF/LTA locus and susceptibility to type 2 diabetes.

  Journal article

  Zeggini E. et al, (2005), Diabetologia, 48, 2013 - 2017

• A large-scale association analysis of common variation of the HNF1alpha gene with type 2 diabetes in the U.K. Caucasian population.

  Journal article

  Weedon MN. et al, (2005), Diabetes, 54, 2487 - 2491

• Susceptibility for latent autoimmune diabetes in adults (LADA) is determined by variation at the 1DDM2 (insulin-gene) locus in white Caucasian patients from UK repositories

  Conference paper

  Desai M. et al, (2005), DIABETOLOGIA, 48, A86 - A86

• Association studies of insulin receptor substrate 1 gene (IRS1) variants in type 2 diabetes samples enriched for family history and early age of onset.

  Journal article

  Zeggini E. et al, (2004), Diabetes, 53, 3319 - 3322

• Analysis of the contribution to type 2 diabetes susceptibility of sequence variation in the gene encoding stearoyl-CoA desaturase, a key regulator of lipid and carbohydrate metabolism.

  Journal article

  Liew CF. et al, (2004), Diabetologia, 47, 2168 - 2175

• Common variants of the hepatocyte nuclear factor-4alpha P2 promoter are associated with type 2 diabetes in the U.K. population.

  Journal article

  Weedon MN. et al, (2004), Diabetes, 53, 3002 - 3006

• Large-scale association studies of candidate genes and their interactions in Type 2 diabetes

  Conference paper

  Zeggini E. et al, (2004), DIABETOLOGIA, 47, A141 - A141

• Role of the D76N polymorphism of insulin promoter factor-1 in predisposing to Type 2 diabetes.

  Journal article

  Owen KR. et al, (2004), Diabetologia, 47, 957 - 958

• Meta-analysis and a large association study confirm a role for calpain-10 variation in type 2 diabetes susceptibility.

  Journal article

  Weedon MN. et al, (2003), Am J Hum Genet, 73, 1208 - 1212

• Genetic variation in the small heterodimer partner gene and young-onset type 2 diabetes, obesity, and birth weight in U.K. subjects.

  Journal article

  Mitchell SM. et al, (2003), Diabetes, 52, 1276 - 1279

• Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility.

  Journal article

  Groves CJ. et al, (2003), Diabetes, 52, 1300 - 1305

• Large-scale association studies of variants in genes encoding the pancreatic β-cell K<inf>ATP</inf> channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes

  Journal article

  Gloyn AL. et al, (2003), Diabetes, 52, 568 - 572

• The genetic architecture of type 2 diabetes.

  Journal article

  Fuchsberger C. et al, Nature, 536, 41 - 47

Recent Publications

• A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk.

  Journal article

  Manning A. et al, (2017), Diabetes, 66, 2019 - 2032

• An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans.

  Journal article

  Scott RA. et al, (2017), Diabetes

• Treatment and outcomes of HNF1A-MODY patients from a specialist monogenic diabetes clinic

  Journal article

  Juszczak A. et al, (2017), DIABETIC MEDICINE, 34, 156 - 156

• Very long duration of optimal diabetes control on Sulphonylurea agents in HNF1A-MODY

  Journal article

  Juszczak A. et al, (2017), DIABETIC MEDICINE, 34, 101 - 101

• Management of hypoglycaemia in people with Type 1 diabetes and referral for transplantation among UK diabetologists: results from a national survey

  Journal article

  Ballav C. et al, (2017), DIABETIC MEDICINE, 34, 114 - 114