Associate Professor of Diabetes
- NIHR Clinician Scientist
- Honorary Consultant Physician
Genetics of Type 2 Diabetes & Monogenic Diabetes
Diabetes arising in young adults has a wide range of underlying aetiologies. This includes genetic causes of beta-cell dysfunction (Maturity-onset diabetes of the young, MODY). We are investigating the characteristics of different subtypes of MODY and how to identify them from those with commoner causes of diabetes. Our research programme aims to implement systematic diagnostics for aetiology of diabetes into routine clinical care. At the moment we are investigating whether there are specific non-genetic biomarkers for MODY subtypes and have recently discovered that low levels of highly-sensitive C-reactive protein are a marker for HNF1A mutations.
Transdermal blood sampling for C-peptide is a minimally invasive, reliable alternative to venous sampling in children and adults with type 1 diabetes
Besser REJ. et al, (2023), Diabetes Care
Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine.
Tobias DK. et al, (2023), Nat Med
Effects of guidance changes for gestational diabetes (GDM) in a UK hospital setting during the covid-19 pandemic: A before and after comparison of management and outcome
HIRST J. et al, (2021), Diabetic Medicine
Diabetes in pregnancy: time to focus on women with type 2 diabetes
HIRST J. et al, (2021), Lancet Diabetes and Endocrinology
Interlaboratory evaluation of plasma N-glycan antennary fucosylation as a clinical biomarker for HNF1A-MODY using liquid chromatography methods.
Demus D. et al, (2021), Glycoconj J