Katharine Owen
Associate Professor of Diabetes
- NIHR Clinician Scientist
- Honorary Consultant Physician
Diabetes arising in young adults has a wide range of underlying aetiologies. This includes genetic causes of beta-cell dysfunction (Maturity-onset diabetes of the young, MODY). We are investigating the characteristics of different subtypes of MODY and how to identify them from those with commoner causes of diabetes. Our research programme aims to implement systematic diagnostics for aetiology of diabetes into routine clinical care. At the moment we are investigating whether there are specific non-genetic biomarkers for MODY subtypes and have recently discovered that low levels of highly-sensitive C-reactive protein are a marker for HNF1A mutations.
Recent publications
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Maturity onset diabetes of the young due to HNF1A variants in Croatia.
Journal article
Pavić T. et al, (2018), Biochem Med (Zagreb), 28
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Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.
Journal article
Turcot V. et al, (2018), Nat Genet, 50, 765 - 766
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Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.
Journal article
Turcot V. et al, (2018), Nat Genet, 50, 766 - 767
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Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.
Flannick J. et al, (2018), Sci Data, 5
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Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.
Journal article
Turcot V. et al, (2018), Nat Genet, 50, 26 - 41