Associate Professor of Diabetes
- NIHR Clinician Scientist
- Honorary Consultant Physician
Genetics of Type 2 Diabetes & Monogenic Diabetes
Diabetes arising in young adults has a wide range of underlying aetiologies. This includes genetic causes of beta-cell dysfunction (Maturity-onset diabetes of the young, MODY). We are investigating the characteristics of different subtypes of MODY and how to identify them from those with commoner causes of diabetes. Our research programme aims to implement systematic diagnostics for aetiology of diabetes into routine clinical care. At the moment we are investigating whether there are specific non-genetic biomarkers for MODY subtypes and have recently discovered that low levels of highly-sensitive C-reactive protein are a marker for HNF1A mutations.
Logistic regression has similar performance to optimised machine learning algorithms in a clinical setting: application to the discrimination between type 1 and type 2 diabetes in young adults
Lynam AL. et al, (2020), Diagnostic and Prognostic Research, 4
Altered cortisol metabolism in individuals with HNF1A-MODY.
Juszczak A. et al, (2020), Clin Endocrinol (Oxf)
A randomised control trial of the effect of lixisenatide on post-meal glucose excursions and glucagon in type 1 diabetes patients.
OWEN K., (2020), Endocrinology, Diabetes and Metabolism
Using data to improve the care of people with diabetes across Oxfordshire
Rea RD. et al, (2020), Practical Diabetes, 37, 27 - 31
Development and validation of multivariable clinical diagnostic models to identify type 1 diabetes requiring rapid insulin therapy in adults aged 18-50 years.
Lynam A. et al, (2019), BMJ Open, 9