DPHIL SUPERVISOR PROFILE
Associate Professor of Cardiovascular Science
Large studies linking common variations to the occurrence of coronary artery disease have enabled us to identify several new genes that may have a causative influence on the susceptibility to developing coronary artery disease. However, for many of these genes the mechanism by which they alter cardiovascular disease pathology is unknown.
Insulin-induced vascular redox dysregulation in human atherosclerosis is ameliorated by dipeptidyl peptidase 4 inhibition.
Akoumianakis I. et al, (2020), Sci Transl Med, 12
A key role for the novel coronary artery disease gene JCAD in atherosclerosis via shear stress mechanotransduction.
Douglas G. et al, (2019), Cardiovasc Res
Adipose tissue-derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases.
Akoumianakis I. et al, (2019), Sci Transl Med, 11
Nox2 contributes to age-related oxidative damage to neurons and the cerebral vasculature.
Fan LM. et al, (2019), J Clin Invest, 130
Adipose Tissue-Derived Wnt5a as a Novel Link Between Obesity and Vascular Disease
Akoumianakis I. et al, (2018), CIRCULATION, 138