Fredrik Karpe
MD/PhD, FRCP
Professor of Metabolic Medicine
- Head of OCDEM
- Honorary Consultant Physician
Oxford Laboratory for Integrative Physiology (Oxlip)
I head the Metabolic Research Group together with Associate Professor Leanne Hodson. My research is focussed on human adipose tissue function and the metabolic consequences of obesity. With increasing rates of obesity and type 2 diabetes, this is an area of unmet clinical need. We are intrigued by strong epidemiological data suggesting opposite associations between the risk of both diabetes and cardiovascular disease vs. upper and lower body obesity. The current research line aims to clarify protective role of gluteofemoral adipose tissue and the metabolically detrimental role of abdominal adipose tissue by studying the tissues at both cellular and whole body level. If one could impose the specialized features of gluteofemoral fat to other tissues, this may lead to interesting new therapeutic approaches.
Recent publications
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The power of genetic diversity in genome-wide association studies of lipids.
Journal article
Graham SE. et al, (2021), Nature
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Increased Risk for Type 2 Diabetes in Relation to Adiposity in Middle-Aged Black South African Men compared to Women
Kufe CN. et al, (2021)
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Publisher Correction: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.
Journal article
Surendran P. et al, (2021), Nat Genet, 53
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A haemagglutination test for rapid detection of antibodies to SARS-CoV-2.
Journal article
Townsend A. et al, (2021), Nat Commun, 12
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Markers of adipose tissue hypoxia are elevated in subcutaneous adipose tissue of severely obese patients with obesity hypoventilation syndrome but not in the moderately obese.
Journal article
Todorčević M. et al, (2021), Int J Obes (Lond)
ORCID
0000-0002-2751-1770