Fredrik Karpe
MD/PhD, FRCP
Professor of Metabolic Medicine
- Head of OCDEM
- Honorary Consultant Physician
Oxford Laboratory for Integrative Physiology (Oxlip)
I head the Metabolic Research Group together with Associate Professor Leanne Hodson. My research is focussed on human adipose tissue function and the metabolic consequences of obesity. With increasing rates of obesity and type 2 diabetes, this is an area of unmet clinical need. We are intrigued by strong epidemiological data suggesting opposite associations between the risk of both diabetes and cardiovascular disease vs. upper and lower body obesity. The current research line aims to clarify protective role of gluteofemoral adipose tissue and the metabolically detrimental role of abdominal adipose tissue by studying the tissues at both cellular and whole body level. If one could impose the specialized features of gluteofemoral fat to other tissues, this may lead to interesting new therapeutic approaches.
Recent publications
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LRP5 promotes adipose progenitor cell fitness and adipocyte insulin sensitivity.
Journal article
Loh NY. et al, (2025), Commun Med (Lond), 5
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Bidirectional Mendelian Randomization Highlights Causal Relationships Between Circulating INHBC and Multiple Cardiometabolic Diseases and Traits.
Journal article
Loh NY. et al, (2024), Diabetes, 73, 2084 - 2094
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Elevations in plasma glucagon are associated with reduced insulin clearance after ingestion of a mixed-macronutrient meal in people with and without type 2 diabetes.
Journal article
Smith K. et al, (2024), Diabetologia, 67, 2555 - 2567
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Body fat distribution and bone mineral density in a multi-ethnic sample of postmenopausal women in The Malaysian Cohort.
Journal article
Bihun H. et al, (2024), Arch Osteoporos, 19
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High-throughput mass spectrometry maps the sepsis plasma proteome and differences in patient response.
Journal article
Mi Y. et al, (2024), Sci Transl Med, 16
ORCID
0000-0002-2751-1770