Francesco Pezzella

FRCP

Professor of Tumour Pathology

Consultant Pathologist

Cancer and blood vessels interaction, the biology of non-angiogenic tumours

The CRUK Tumour Pathology Group is an integral part of the CRUK Oxford Cancer Centre directed by Professor Adrian Harris. It exists to provide academic pathology support to the other constituent groups within that centre and to perform independent research. Currently the major topic of the group concerns tumour angiogenesis, hypoxia and cell cycle. Each member of the group has specific projects that are reviewed at the weekly unit meetings and include the production of monoclonal antibodies, immunohistochemistry, in situ hybridisation and the use of DNA and tissue microarrays.

Key publications

Evidence Showing That Tumors Can Grow Without Angiogenesis and Can Switch Between Angiogenic and Nonangiogenic Phenotypes.
Journal article

Pezzella F. and Gatter KC., (2016), J Natl Cancer Inst, 108
When cancer co-opts the vasculature.
Journal article

Pezzella F. and Harris AL., (2014), N Engl J Med, 370, 2146 - 2147

Recent publications

Early squamous cell lung carcinoma: prognostic biomarkers for the many.
Journal article

Pezzella F., (2019), Thorax, 74, 527 - 528
The Role of JMY in p53 Regulation.
Journal article

Adighibe O. and Pezzella F., (2018), Cancers (Basel), 10
Association between hypoxic volume and underlying hypoxia-induced gene expression in oropharyngeal squamous cell carcinoma.
Journal article

Suh Y-E. et al, (2017), Br J Cancer, 116, 1057 - 1064
RNA Sequencing Reveals that Kaposi Sarcoma-Associated Herpesvirus Infection Mimics Hypoxia Gene Expression Signature.
Journal article

Viollet C. et al, (2017), PLoS Pathog, 13
Inhibition of NEDD8 and FAT10 ligase activities through the degrading enzyme NEDD8 ultimate buster 1: A potential anticancer approach.
Journal article

Tan K-L. and Pezzella F., (2016), Oncol Lett, 12, 4287 - 4296

More publications