Contact information
Research groups
Francesco Pezzella
FRCP
Professor of Tumour Pathology
- Consultant Pathologist
Cancer and blood vessels interaction, the biology of non-angiogenic tumours
The CRUK Tumour Pathology Group is an integral part of the CRUK Oxford Cancer Centre directed by Professor Adrian Harris. It exists to provide academic pathology support to the other constituent groups within that centre and to perform independent research. Currently the major topic of the group concerns tumour angiogenesis, hypoxia and cell cycle. Each member of the group has specific projects that are reviewed at the weekly unit meetings and include the production of monoclonal antibodies, immunohistochemistry, in situ hybridisation and the use of DNA and tissue microarrays.
Key publications
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Evidence Showing That Tumors Can Grow Without Angiogenesis and Can Switch Between Angiogenic and Nonangiogenic Phenotypes.
Journal article
Pezzella F. and Gatter KC., (2016), J Natl Cancer Inst, 108
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When cancer co-opts the vasculature.
Journal article
Pezzella F. and Harris AL., (2014), N Engl J Med, 370, 2146 - 2147
Recent publications
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Early squamous cell lung carcinoma: prognostic biomarkers for the many.
Journal article
Pezzella F., (2019), Thorax, 74, 527 - 528
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The Role of JMY in p53 Regulation.
Journal article
Adighibe O. and Pezzella F., (2018), Cancers (Basel), 10
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Association between hypoxic volume and underlying hypoxia-induced gene expression in oropharyngeal squamous cell carcinoma.
Journal article
Suh Y-E. et al, (2017), Br J Cancer, 116, 1057 - 1064
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RNA Sequencing Reveals that Kaposi Sarcoma-Associated Herpesvirus Infection Mimics Hypoxia Gene Expression Signature.
Journal article
Viollet C. et al, (2017), PLoS Pathog, 13
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Inhibition of NEDD8 and FAT10 ligase activities through the degrading enzyme NEDD8 ultimate buster 1: A potential anticancer approach.
Journal article
Tan K-L. and Pezzella F., (2016), Oncol Lett, 12, 4287 - 4296