DPHIL PROJECTS AVAILABLE
MBChB, MRCP, PhD
University Research Lecturer
- British Heart Foundation Intermediate Clinical Research Fellow
Cell and Molecular Biology
My work focuses on understanding how obesity leads to the development of diabetes and cardiovascular disease. In particular, my research aims to understand how a family of growth factors, known as Wnts regulates adipocyte number (adipose tissue 'expandability') and distribution within the body; two key determinants of susceptibility to obesity-associated cardiometabolic disease. In order to achieve this we employ human genetic and physiological approaches, accompanied by functional studies in human fat depot-specific cellular models. Recently we identified a key Wnt receptor, LRP5, as a novel human fat distribution gene.
Of interest LRP5 is a current drug target for the treatment of osteoporosis illustrating the translational potential of the research. In the longer term we hope to exploit our findings to develop novel therapies for obesity and cardiometabolic diseases.
I am currently a BHF Intermediate Clinical Research Fellow and Honorary Consultant in Endocrinology and Diabetes. Prior to this I competed my PhD at the University of Cambridge before taking up an Academic Clinical Lecturer post at the University of Oxford.
Triglyceride-lowering LPL alleles combined with LDL-C-lowering alleles are associated with an additively improved lipoprotein profile.
Ibi D. et al, (2021), Atherosclerosis
Investigating the relationships between unfavourable habitual sleep and metabolomic traits: evidence from multicohort multivariable regression and Mendelian randomization analyses
CHRISTODOULIDES C., (2021), BMC Medicine
Associations between outdoor temperature and bright sunlight with metabolites in two population-based European cohorts.
Eveleens Maarse BC. et al, (2020), Nutr Metab Cardiovasc Dis, 30, 2252 - 2261
Hedgehog signalling as a determinant of human fat expansion and distribution
van Dam AD. et al, (2020), DIABETOLOGIA, 63, S57 - S58
RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro.
Loh NY. et al, (2020), Nat Commun, 11