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Clara Pavillet

BSc (Hons), MSc (Oxon)

DPhil Student

I am a DPhil student from the Medical Sciences Doctoral Training Centre and MRC Weatherall Institute of Molecular Medicine specialising in Computational Biology and Bioinformatics (see more) with Prof. Francesca Buffa (Computational Genomics) and Prof. Tudor Fulga (Genome Engineering and Vice President Gene Editing at Vertex Pharmaceuticals). I am a member of Keble College, and I am fully-funded by the University of Oxford and the Wellcome Trust.

Originally from France and having lived in South America and North America, I am fluent in French, Spanish and English. I graduated from the University of Toronto in 2016 with a BSc (Hons) in Biochemistry and Immunology taking a broad range of courses in both the physical and medical sciences. In parallel to my studies, I conducted research at the Hospital for Sick Children’s Peter Gilgan Centre for Research and Learning from 2014 to 2016. My undergraduate thesis under the supervision of Prof. Jean-Philippe Julien was on the HIV-1 glycoprotein, and structure-based protein design strategies to elicit neutralising antibodies against the virus (see more). My fascination with RNA viruses then led me to the Instituto de Investigaciones Biomédicas en Retrovirus y SIDA (INBIRS) at the University of Buenos Aires with Prof. Jorge Geffner and Dr. Federico Remes Lenicov.

Thereafter, I pursued graduate studies at the University of Oxford where I further combined an interest in systems biology, mathematical modelling and physics in a master's thesis supervised by Prof. Francesca Buffa before starting my DPhil in 2017. My first year modules included: Statistics, Advanced Genomics, Advanced Proteomics, Programming, Advanced Microscopy, Genome Engineering. I then undertook three rotation projects in different research groups at the Department of Biochemistry1, Sir William Dunn School of Pathology2 and MRC WIMM Centre for Computational Biology3:

  • Single-Molecule Fluorescence In Situ Hybridization Image Analysis of RNA Transcripts Involved in Brain Development1 (see more)
  • Predicting Oxford Nanopore Base-Calling Errors to Improve the Performance of a Hidden Markov Model Identifying DNA Base Analogues2 (see more)
  • Deep Learning Model to Predict tRNA Promoter and Processing Activities for gRNA Expression used in CRISPR Genome Editing3 (see more)

My main DPhil project lies at the intersection of computer code (01) and genetic code (ACTG) modelling the immune response to tackle disease. Specifically, I am investigating T cell-mediated immune responses using large-scale genomics data to develop mathematical, statistical and computational models for drug discovery.

Recent publications

More publications