Research groups

Antoniades Group: The Oxford Translational Cardiovascular Research Group

Websites

British Heart Foundation
Funding body
Oxford Heart Vessels and Fat (ox-HVF) cohort
Prospective translational programme
Cardiovascular Research
Journal
Reuters video on FAI technology
Press
British Atherosclerosis Society
National Society
The Lancet 2024
Video

Charalambos Antoniades

British Heart Foundation Chair of Cardiovascular Medicine

Director, Acute Multidisciplinary Imaging and Interventional Centre (AMIIC)
Deputy Head, Division of Cardiovascular Medicine
Professor of Cardiovascular Medicine
Honorary Consultant Cardiologist
Chair of the British Atherosclerosis Society

Crosstalk between adipose tissue and the cardiovascular system: From target discovery to advanced imaging and risk prediction

Adipose tissue is now considered to be a “biochemical factory” in the human body, producing a wide range of bioactive molecules, such as adipokines. These molecules exert local autocrine effects, but they also have paracrine and endocrine properties, and may play a critical role in the regulation of redox state and signalling in various tissues, such as the vascular wall and myocardium. Our group studies the mechanisms by which different adipose tissue depots in the human body affect vascular and myocardial redox state in atherosclerosis. We also search for novel therapeutic strategies targeting vascular and myocardial redox signalling directly or through changes in the crosstalk between adipose tissue and cardiovascular system.

Our group undertakes translational research, moving from bench to bedside and vice versa. We use various clinical research tools, such as non-invasive imaging and others, for the evaluation of vascular / myocardial function. This includes studies on human tissues; we have developed a number of ex vivo models of human tissue (vessels, myocardium and adipose tissue) for translational research, which are complemented by tissue and cell culture techniques. We have also established a large bioresource of human vascular, myocardial and adipose tissue in collaboration with other academic institutions across the world (The Oxford Heart Vessels & Fat (ox-HVF) cohort) and this is currently being used to support hypothesis driven research in the field of vascular and myocardial redox state regulation.

In our lab state-of-the-art techniques are used to visualise and quantify vascular and myocardial free radical production.

Using genetic tools to identify patients with pre-specified genetic traits, enables us to apply a “recruit-by-genotype” approach to address biological questions related to the cross-talk between adipose tissue and vascular/myocardial redox signalling in human cardiovascular disease.

We are also using state-of-the-art non-invasive imaging techniques (advanced ultrasound and CT imaging techniques) to study the structure and function of the cardiovascular system and explore its interactions with the adipose tissue. This programme of work led to the recent discovery of the "inside-to-outside" signals from the human cardiovascular system to the adipose tissue, and allowed the development of new clinical applications of cardiovascular imaging.

Since 2015, the group runs the Oxford Cardiovascular Computed Tomography programme, in partnership with the Manor Hospital, supporting the use of state-of-the-art cardiovascular CT imaging by groups within the University of Oxford. The group is using artificial intellience and machine learning approaches to analyse radiotranscriptomic signatures that lead to the develpment of new imaging biomarkers. A recent example is that of the develpment of Fat Attenuation Index (FAI), a new biomarker that detects inflammation in the human coronary arteries by analysing the changes of weighed CT attenuation of perivascular adipose tissue (Science Transl Med 2017). FAI has striking predictive value for cardiac mortality and acute coronary events, as demonstrated in a large prospective clinical study (CRISP-CT) organised together with Erlangen University (Germany) and Cleveland Clinic (USA) (Lancet 2018).

Since 2015, the group runs the Oxford Academic cardiovascular Computed Tomography (OXACCT) programme, in partnership with the Manor Hospital, supporting the use of state-of-the-art cardiovascular CT imaging by groups within the University of Oxford. Within the group, we run the OXACCT Core Lab, peforming advanced analysis of cardiovascular CT images with specific focus on analysis of coronary plaques and perivascular adipose tissue.

Our group also organises small-scale randomised clinical trials that include extensive cardiovascular phenotyping, testing the effects of treatments (statins, folates etc) on the biology of the human vascular wall, myocardium and adipose tissue.

Key publications

Inflammatory risk and cardiovascular events in patients without obstructive coronary artery disease: the ORFAN multicentre, longitudinal cohort study.

Chan K. et al, (2024), Lancet, 403, 2606 - 2618

Constructing custom-made radiotranscriptomic signatures of vascular inflammation from routine CT angiograms: a prospective outcomes validation study in COVID-19.

Kotanidis CP. et al, (2022), Lancet Digit Health, 4, e705 - e716

Effects of canagliflozin on human myocardial redox signalling: clinical implications.

Kondo H. et al, (2021), Eur Heart J, 42, 4947 - 4960

Standardized measurement of coronary inflammation using cardiovascular computed tomography: integration in clinical care as a prognostic medical device.

Oikonomou EK. et al, (2021), Cardiovasc Res, 117, 2677 - 2690

Insulin-induced vascular redox dysregulation in human atherosclerosis is ameliorated by dipeptidyl peptidase 4 inhibition.

Akoumianakis I. et al, (2020), Sci Transl Med, 12

Imaging residual inflammatory cardiovascular risk.

Antoniades C. et al, (2020), Eur Heart J, 41, 748 - 758

A novel machine learning-derived radiotranscriptomic signature of perivascular fat improves cardiac risk prediction using coronary CT angiography.

Oikonomou EK. et al, (2019), Eur Heart J, 40, 3529 - 3543

Adipose tissue-derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases.

Akoumianakis I. et al, (2019), Sci Transl Med, 11

Association of Biologic Therapy With Coronary Inflammation in Patients With Psoriasis as Assessed by Perivascular Fat Attenuation Index.

Elnabawi YA. et al, (2019), JAMA Cardiol, 4, 885 - 891

Non-invasive detection of coronary inflammation using computed tomography and prediction of residual cardiovascular risk (the CRISP CT study): a post-hoc analysis of prospective outcome data.

Oikonomou EK. et al, (2018), Lancet, 392, 929 - 939

Detecting human coronary inflammation by imaging perivascular fat.

Antonopoulos AS. et al, (2017), Sci Transl Med, 9

Mutual Regulation of Epicardial Adipose Tissue and Myocardial Redox State by PPAR-γ/Adiponectin Signalling.

Antonopoulos AS. et al, (2016), Circ Res, 118, 842 - 855

Adiponectin as a link between type 2 diabetes and vascular NADPH oxidase activity in the human arterial wall: the regulatory role of perivascular adipose tissue.

Antonopoulos AS. et al, (2015), Diabetes, 64, 2207 - 2219

Interactions between vascular wall and perivascular adipose tissue reveal novel roles for adiponectin in the regulation of endothelial nitric oxide synthase function in human vessels.

Margaritis M. et al, (2013), Circulation, 127, 2209 - 2221

Myocardial redox state predicts in-hospital clinical outcome after cardiac surgery effects of short-term pre-operative statin treatment.

Antoniades C. et al, (2012), J Am Coll Cardiol, 59, 60 - 70

Induction of vascular GTP-cyclohydrolase i and endogenous tetrahydrobiopterin synthesis protect against inflammation-induced endothelial dysfunction in human atherosclerosis

Antoniades C. et al, (2011), Circulation, 124, 1860 - 1870

Rapid, direct effects of statin treatment on arterial redox state and nitric oxide bioavailability in human atherosclerosis via tetrahydrobiopterin-mediated endothelial nitric oxide synthase coupling.

Antoniades C. et al, (2011), Circulation, 124, 335 - 345

Preoperative atorvastatin treatment in CABG patients rapidly improves vein graft redox state by inhibition of Rac1 and NADPH-oxidase activity.

Antoniades C. et al, (2010), Circulation, 122, S66 - S73

The CD40/CD40 ligand system: linking inflammation with atherothrombosis.

Antoniades C. et al, (2009), J Am Coll Cardiol, 54, 669 - 677

Altered plasma versus vascular biopterins in human atherosclerosis reveal relationships between endothelial nitric oxide synthase coupling, endothelial function, and inflammation.

Antoniades C. et al, (2007), Circulation, 116, 2851 - 2859

Global improvement of vascular function and redox state with low-dose folic acid: implications for folate therapy in patients with coronary artery disease.

Shirodaria C. et al, (2007), Circulation, 115, 2262 - 2270

Genetic polymorphisms of platelet glycoprotein Ia and the risk for premature myocardial infarction: effects on the release of sCD40L during the acute phase of premature myocardial infarction.

Antoniades C. et al, (2006), J Am Coll Cardiol, 47, 1959 - 1966

Recent publications

Coronary Inflammation Is Associated With Plaque Progression in Men With HIV.

Nasrallah N. et al, (2026), Circ Cardiovasc Imaging

Non-invasive assessment of coronary inflammation improves the diagnostic accuracy of coronary death in post-mortem CT angiography.

Xie C. et al, (2026), J Cardiovasc Comput Tomogr

Pathophysiology, prevention, and management of coronary microvascular obstruction.

Cenko E. et al, (2026), Eur Heart J

Early Prediction of Heart Failure From Routine Cardiac CT Using Radiomic Phenotyping of Epicardial Fat.

Oikonomou EK. et al, (2026), J Am Coll Cardiol

Reimagining Thomas Lewis's perspective: using artificial intelligence tools to predict cardiovascular risk from computed tomography.

Kotronias RA. et al, (2026), Heart

Imaging and Quantification of Perivascular Adipose Tissue.

Foran D. et al, (2026), Arterioscler Thromb Vasc Biol, 46

Anatomical, physiological and inflammatory characterization of nonculprit vessels in patients undergoing primary PCI for ST-elevation myocardial infarction in the presence of multivessel disease: Rationale and design of the PICNIC study.

Mahmoudi M. et al, (2026), Am Heart J, 292

Effectiveness of a novel intervention (Super Rehab) in overweight patients with atrial fibrillation (SuRe AF): protocol for a randomised controlled trial.

Murphy D. et al, (2025), BMJ Open, 15

Expression of Concern for Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction.

Meakin PJ. et al, (2025), J Clin Invest, 135

From lipids and inflammation to artificial intelligence-driven therapeutics: the 93rd European atherosclerosis society (EAS) congress 2025 in focus.

Gurgone D. et al, (2025), Cardiovasc Res, 121, 1302 - 1305

Pericoronary Adipose Tissue Imaging and the Need for Standardized Measurement of Coronary Inflammation: Translating PCAT Attenuation Gradients Into FAI Score for Clinical Use.

Antoniades C. and Chan K., (2025), JACC Cardiovasc Imaging, 18, 895 - 898

Coronary inflammation and cardiovascular risk in breast cancer after radiotherapy.

Kotanidis CP. et al, (2025), Eur Heart J, 46, 2924 - 2927

Scalable screening for structural heart disease: promises from artificial intelligence-electrocardiogram tools.

Antoniades C. and Chan K., (2025), Eur Heart J Digit Health, 6, 521 - 523

Cost-effectiveness of a novel AI technology to quantify coronary inflammation and cardiovascular risk in patients undergoing routine coronary computed tomography angiography.

Tsiachristas A. et al, (2025), Eur Heart J Qual Care Clin Outcomes, 11, 434 - 444

Benchmarking Photon-Counting Computed Tomography Angiography Against Invasive Assessment of Coronary Stenosis: Implications for Severely Calcified Coronaries.

Kotronias RA. et al, (2025), JACC Cardiovasc Imaging, 18, 572 - 585

Using artificial intelligence to spot heart failure from ECGs: is it prime time?

Antoniades C. and Chan K., (2025), Eur Heart J, 46, 1054 - 1056

Assessing the impact of COmorbidities and Sociodemographic factors on Multiorgan Injury following COVID-19: rationale and protocol design of COSMIC, a UK multicentre observational study of COVID-negative controls.

Shergill S. et al, (2025), BMJ Open, 15

Obesity and cardiovascular disease: an ESC clinical consensus statement.

Koskinas KC. et al, (2025), Eur J Prev Cardiol, 32, 184 - 220

Intra-operative and post-operative management of conduits for coronary artery bypass grafting: a clinical consensus statement of the European Society of Cardiology Working Group on Cardiovascular Surgery and the European Association for Cardio-Thoracic Surgery Coronary Task Force.

Sandner S. et al, (2025), Eur Heart J, 46, 19 - 34

Using artificial intelligence to study atherosclerosis from computed tomography imaging: A state-of-the-art review of the current literature.

Klüner LV. et al, (2024), Atherosclerosis, 398

Inflammatory risk and cardiovascular events in patients without obstructive coronary artery disease: the ORFAN multicentre, longitudinal cohort study.

Chan K. et al, (2024), Lancet, 403, 2606 - 2618

Photon-counting computed tomography: 'one-stop shop' for coronary stenosis, inflammation, and myocardial assessment in ST-segment elevation acute coronary syndrome.

Kotronias RA. et al, (2024), Eur Heart J Cardiovasc Imaging, 25

Seeing Is Believing: Photon Counting Computed Tomography Clearly Images Directional Deep Brain Stimulation Lead Segments and Markers After Implantation.

Manfield J. et al, (2024), Neuromodulation, 27, 557 - 564

Deep-Learning for Epicardial Adipose Tissue Assessment With Computed Tomography: Implications for Cardiovascular Risk Prediction.

West HW. et al, (2023), JACC Cardiovasc Imaging, 16, 800 - 816

Assessment of Cardiac Energy Metabolism, Function, and Physiology in Patients With Heart Failure Taking Empagliflozin: The Randomized, Controlled EMPA-VISION Trial.

Hundertmark MJ. et al, (2023), Circulation, 147, 1654 - 1669

High resolution photon counting CT permits direct visualisation of directional deep brain stimulation lead segments and markers.

Manfield J. et al, (2023), Brain Stimul, 16, 1276 - 1277

Lipoprotein(a) Regulates Vascular Redox State and Predicts Adverse Cardiovascular Outcomes in Coronary Artery Disease

Polkinghorne MD. et al, (2023), CIRCULATION, 148

Genetic variability of lipoprotein(a) controls vascular inflammation/redox signalling and predicts adverse cardiovascular outcomes in coronary artery disease N.

Polkinghorne MD. et al, (2023), EUROPEAN HEART JOURNAL, 44

Human epicardial adipose tissue-secreted miR-92a-3p regulates myocardial redox state via paracrine signalling: implications for cardiovascular clinical outcomes

Badi I. et al, (2023), EUROPEAN HEART JOURNAL, 44

The Role of Perivascular Fat in the Diagnosis and Prognosis of Atherosclerosis

Polkinghorne M. et al, (2023), CardioMetabolic Syndrome Journal, 3, 8 - 8

Mechanisms, therapeutic implications, and methodological challenges of gut microbiota and cardiovascular diseases: a position paper by the ESC Working Group on Coronary Pathophysiology and Microcirculation.

Tousoulis D. et al, (2022), Cardiovasc Res, 118, 3171 - 3182

Non-canonical WNT signalling in cardiovascular disease: mechanisms and therapeutic implications.

Akoumianakis I. et al, (2022), Nat Rev Cardiol, 19, 783 - 797

Noninvasive Plaque Imaging to Accelerate Coronary Artery Disease Drug Development.

Figtree GA. et al, (2022), Circulation, 146, 1712 - 1727

Pericardial adiposity is independently linked to adverse cardiovascular phenotypes: a CMR study of 42 598 UK Biobank participants.

Ardissino M. et al, (2022), Eur Heart J Cardiovasc Imaging, 23, 1471 - 1481

Constructing custom-made radiotranscriptomic signatures of vascular inflammation from routine CT angiograms: a prospective outcomes validation study in COVID-19.

Kotanidis CP. et al, (2022), Lancet Digit Health, 4, e705 - e716

Novel Biomarkers for Risk Stratification in NSTE-ACS: Is There a Place for Cathepsin S?

Antoniades C. and Polkinghorne MD., (2022), J Am Coll Cardiol, 80, 1011 - 1013

Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study.

PHOSP-COVID Collaborative Group ., (2022), Lancet Respir Med, 10, 761 - 775

Corrigendum to: Uncovering the skeleton in the heart: an unusual case of mitral annular calcification extending to the left ventricular myocardium.

Nikolaidou C. et al, (2022), Eur Heart J Cardiovasc Imaging, 23

Visceral adipose tissue phenotype and hypoadiponectinemia are associated with aortic Fluorine-18 fluorodeoxyglucose uptake in patients with familial dyslipidemias.

Toutouzas K. et al, (2022), J Nucl Cardiol, 29, 1405 - 1414

Standardized measurement of coronary inflammation using cardiovascular computed tomography: integration in clinical care as a prognostic medical device.

Oikonomou EK. et al, (2021), Cardiovasc Res, 117, 2677 - 2690

CT coronary angiography-guided cardiovascular risk screening in asymptomatic patients: is it time?

Graby J. et al, (2021), Clin Radiol, 76, 801 - 811

Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study.

Evans RA. et al, (2021), Lancet Respir Med, 9, 1275 - 1287

A phenomapping-derived tool to personalize the selection of anatomical vs. functional testing in evaluating chest pain (ASSIST).

Oikonomou EK. et al, (2021), Eur Heart J, 42, 2536 - 2548

Inflammatory Mechanisms in COVID-19 and Atherosclerosis: Current Pharmaceutical Perspectives.

Sagris M. et al, (2021), Int J Mol Sci, 22

Cardiac Magnetic Resonance to Detect the Underlying Substrate in Patients with Frequent Idiopathic Ventricular Arrhythmias.

Nikolaidou C. et al, (2021), Diagnostics (Basel), 11

Reply to: Quantification of perivascular inflammation does not provide incremental prognostic value over myocardial perfusion imaging and calcium scoring.

Antonopoulos AS. and Antoniades C., (2021), Eur J Nucl Med Mol Imaging, 48, 1707 - 1708

Development, validation, and implementation of biomarker testing in cardiovascular medicine state-of-the-art: proceedings of the European Society of Cardiology-Cardiovascular Round Table.

Elliott P. et al, (2021), Cardiovasc Res, 117, 1248 - 1256

Medium-term effects of SARS-CoV-2 infection on multiple vital organs, exercise capacity, cognition, quality of life and mental health, post-hospital discharge.

Raman B. et al, (2021), EClinicalMedicine, 31

Uncovering the skeleton in the heart: an unusual case of mitral annular calcification extending to the left ventricular myocardium.

Nikolaidou C. et al, (2020), Eur Heart J Cardiovasc Imaging, 21

A link between inflammation and thrombosis in atherosclerotic cardiovascular diseases: Clinical and therapeutic implications.

Oikonomou E. et al, (2020), Atherosclerosis, 309, 16 - 26

Insulin-induced vascular redox dysregulation in human atherosclerosis is ameliorated by dipeptidyl peptidase 4 inhibition.

Akoumianakis I. et al, (2020), Sci Transl Med, 12

Perivascular Adipose Tissue and Atherosclerosis

Kotanidis C. and ANTONIADES C., (2020), 91 - 115

Using Perivascular Fat Attenuation Index to Monitor Coronary Inflammation in Patients With Psoriasis-Reply.

Elnabawi YA. et al, (2020), JAMA Cardiol, 5, 359 - 360

Preventing treatment failures in coronary artery disease: what can we learn from the biology of in-stent restenosis, vein graft failure, and internal thoracic arteries?

Spadaccio C. et al, (2020), Cardiovasc Res, 116, 505 - 519

Plasma signature of apoptotic microvesicles is associated with endothelial dysfunction and plaque rupture in acute coronary syndromes.

Zacharia E. et al, (2020), J Mol Cell Cardiol, 138, 110 - 114

Medium-term effects of SARS-CoV-2 infection on multiple vital organs, exercise capacity, cognition, quality of life and mental health, post-hospital discharge

Raman B. et al, (2020)

Scientists on the Spot: non-coding RNAs and heart failure.

Antoniades C. and Condorelli G., (2019), Cardiovasc Res, 115, e164 - e165

Very low calorie diets are associated with transient ventricular impairment before reversal of diastolic dysfunction in obesity.

Rayner JJ. et al, (2019), Int J Obes (Lond), 43, 2536 - 2544

A novel machine learning-derived radiotranscriptomic signature of perivascular fat improves cardiac risk prediction using coronary CT angiography.

Oikonomou EK. et al, (2019), Eur Heart J, 40, 3529 - 3543

Cardiac Computed Tomography: Assessment of Coronary Inflammation and Other Plaque Features.

Oikonomou EK. et al, (2019), Arterioscler Thromb Vasc Biol, 39, 2207 - 2219

Arterial Grafts for Coronary Bypass: A Critical Review After the Publication of ART and RADIAL.

Gaudino M. et al, (2019), Circulation, 140, 1273 - 1284

Detecting Coronary Inflammation With Perivascular Fat Attenuation Imaging: Making Sense From Perivascular Attenuation Maps.

Antoniades C. and Shirodaria C., (2019), JACC Cardiovasc Imaging, 12, 2011 - 2014

Adipose tissue-derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases.

Akoumianakis I. et al, (2019), Sci Transl Med, 11

Association of Biologic Therapy With Coronary Inflammation in Patients With Psoriasis as Assessed by Perivascular Fat Attenuation Index.

Elnabawi YA. et al, (2019), JAMA Cardiol, 4, 885 - 891

State-of-the-art review article. Atherosclerosis affecting fat: What can we learn by imaging perivascular adipose tissue?

Antoniades C. et al, (2019), J Cardiovasc Comput Tomogr, 13, 288 - 296

Non-invasive detection of coronary inflammation using computed tomography and prediction of residual cardiovascular risk (the CRISP CT study): a post-hoc analysis of prospective outcome data.

Oikonomou EK. et al, (2018), Lancet, 392, 929 - 939

Off-Pump Coronary Artery Bypass Grafting: 30 Years of Debate.

Gaudino M. et al, (2018), J Am Heart Assoc, 7

Cardiac Magnetic Resonance Imaging of Epicardial and Intramyocardial Adiposity as an Early Sign of Myocardial Disease.

Antonopoulos AS. and Antoniades C., (2018), Circ Cardiovasc Imaging, 11

Development and Validation of a Clinical Score for Cardiovascular Risk Stratification of Long-Term Childhood Cancer Survivors.

Oikonomou EK. et al, (2018), Oncologist, 23, 965 - 973

Comparison of graft patency following coronary artery bypass grafting in the left versus the right coronary artery systems: a systematic review and meta-analysis.

Pinho-Gomes A-C. et al, (2018), Eur J Cardiothorac Surg, 54, 221 - 228

Vascular inflammation and metabolic activity in hematopoietic organs and liver in familial combined hyperlipidemia and heterozygous familial hypercholesterolemia.

Toutouzas K. et al, (2018), J Clin Lipidol, 12, 33 - 43

Predictive value of telomere length on outcome following acute myocardial infarction: evidence for contrasting effects of vascular vs. blood oxidative stress.

Margaritis M. et al, (2017), Eur Heart J, 38, 3094 - 3104

A novel workflow combining plaque imaging, plaque and plasma proteomics identifies biomarkers of human coronary atherosclerotic plaque disruption.

Lee R. et al, (2017), Clin Proteomics, 14

Scientists of Tomorrow at the Frontiers of Cardiovascular Biology 2016 in Florence: translating basic science into clinical practice is the next frontier.

Antoniades C. et al, (2016), Cardiovasc Res, 111, 120 - 122

Expert consensus document: Defining the major health modifiers causing atrial fibrillation: a roadmap to underpin personalized prevention and treatment.

Fabritz L. et al, (2016), Nat Rev Cardiol, 13, 230 - 237

Biomarkers of oxidative stress following continuous positive airway pressure withdrawal: data from two randomised trials.

Stradling JR. et al, (2015), Eur Respir J, 46, 1065 - 1071

Homoarginine in the shadow of asymmetric dimethylarginine: from nitric oxide to cardiovascular disease.

Papageorgiou N. et al, (2015), Amino Acids, 47, 1741 - 1750

Homoarginine in the shadow of asymmetric dimethylarginine: from nitric oxide to cardiovascular disease

Papageorgiou N. et al, (2015), Amino Acids, 47, 1741 - 1750

Differences in arterial stiffness and target organ damage between native Greek patients and immigrants from Eastern European countries with essential hypertension.

Katsi V. et al, (2015), Int Angiol, 34, 407 - 412

Redox biomarkers in cardiovascular medicine.

Karimi Galougahi K. et al, (2015), Eur Heart J, 36, 1576 - b

Adiponectin as a link between type 2 diabetes and vascular NADPH oxidase activity in the human arterial wall: the regulatory role of perivascular adipose tissue.

Antonopoulos AS. et al, (2015), Diabetes, 64, 2207 - 2219

Impact of folic acid administration in homocysteine levels, inflammation and in atherosclerotic plaque area in apoE deficient mice.

Tousoulis D. et al, (2014), Int J Cardiol, 177, 696 - 697

Combined effects of smoking and interleukin-6 and C-reactive protein genetic variants on endothelial function, inflammation, thrombosis and incidence of coronary artery disease.

Hatzis G. et al, (2014), Int J Cardiol, 176, 254 - 257

Reciprocal effects of systemic inflammation and brain natriuretic peptide on adiponectin biosynthesis in adipose tissue of patients with ischemic heart disease.

Antonopoulos AS. et al, (2014), Arterioscler Thromb Vasc Biol, 34, 2151 - 2159

Combined effects of smoking and interleukin-6 and C-reactive protein genetic variants on endothelial function, inflammation, thrombosis and incidence of coronary artery disease

Hatzis G. et al, (2014), International Journal of Cardiology, 176, 254 - 257

Reciprocal effects of systemic inflammation and brain natriuretic peptide on adiponectin biosynthesis in adipose tissue of patients with ischemic heart disease

Antonopoulos AS. et al, (2014), Arteriosclerosis Thrombosis and Vascular Biology, 34, 2151 - 2159

Combined effects of fibrinogen genetic variability on atherosclerosis in patients with or without stable angina pectoris: focus on the coagulation cascade and endothelial function.

Papageorgiou N. et al, (2013), Int J Cardiol, 168, 4602 - 4607

Combined effects of fibrinogen genetic variability on atherosclerosis in patients with or without stable angina pectoris: Focus on the coagulation cascade and endothelial function

Papageorgiou N. et al, (2013), International Journal of Cardiology, 168, 4602 - 4607

The role of C-reactive protein genetic variability in the onset of carotid artery disease and renal function impairment in patients with diabetes mellitus type 2.

Papaoikonomou S. et al, (2013), Int J Cardiol, 168, 4331 - 4332

Inflammation and right ventricle: the hunting of the missing link.

Papageorgiou N. et al, (2013), Int J Cardiol, 168, 3152 - 3154

Inflammation and right ventricle: The hunting of the missing link

Papageorgiou N. et al, (2013), International Journal of Cardiology, 168, 3152 - 3154

The role of C-reactive protein genetic variability in the onset of carotid artery disease and renal function impairment in patients with diabetes mellitus type 2

Papaoikonomou S. et al, (2013), International Journal of Cardiology, 168, 4331 - 4332

The impact of G5665T polymorphism of endothelin-1 gene, on endothelin-1 levels and left ventricular function in ischemic heart disease.

Tousoulis D. et al, (2013), Int J Cardiol, 168, 1568 - 1569

Artifactual elevation of plasma sCD40L by residual platelets in patients with coronary artery disease.

Lee R. et al, (2013), Int J Cardiol, 168, 1648 - 1650

Artifactual elevation of plasma sCD40L by residual platelets in patients with coronary artery disease

Lee R. et al, (2013), International Journal of Cardiology, 168, 1648 - 1650

The impact of G5665T polymorphismof endothelin-1 gene, on endothelin-1 levels and left ventricular function in ischemic heart disease

Tousoulis D. et al, (2013), International Journal of Cardiology, 168, 1568 - 1569

Genetic variability on adiponectin gene affects myocardial infarction risk: the role of endothelial dysfunction.

Antonopoulos AS. et al, (2013), Int J Cardiol, 168, 326 - 330

Genetic variability on adiponectin gene affects myocardial infarction risk: The role of endothelial dysfunction

Antonopoulos AS. et al, (2013), International Journal of Cardiology, 168, 326 - 330

Interactions between vascular wall and perivascular adipose tissue reveal novel roles for adiponectin in the regulation of endothelial nitric oxide synthase function in human vessels.

Margaritis M. et al, (2013), Circulation, 127, 2209 - 2221

Improved limb perfusion and neoangiogenesis after intramuscular erythropoietin infusion in experimental model of limb ischemia.

Tousoulis D. et al, (2013), Int J Cardiol, 165, 195 - 197

Improved limb perfusion and neoangiogenesis after intramuscular erythropoietin infusion in experimental model of limb ischemia

Tousoulis D. et al, (2013), International Journal of Cardiology, 165, 195 - 197

Systemic and vascular oxidation limits the efficacy of oral tetrahydrobiopterin treatment in patients with coronary artery disease.

Cunnington C. et al, (2012), Circulation, 125, 1356 - 1366

Systemic and vascular oxidation limits the efficacy of oral tetrahydrobiopterin treatment in patients with coronary artery disease

Cunnington C. et al, (2012), Circulation, 125, 1356 - 1366

Effects of atorvastatin on endothelial function and the expression of proinflammatory cytokines and adhesion molecules in young subjects with successfully repaired coarctation of aorta.

Brili S. et al, (2012), Heart, 98, 325 - 329

Effects of atorvastatin on endothelial function and the expression of proinflammatory cytokines and adhesion molecules in young subjects with successfully repaired coarctation of aorta

Brili S. et al, (2012), Heart, 98, 325 - 329

Myocardial redox state predicts in-hospital clinical outcome after cardiac surgery effects of short-term pre-operative statin treatment.

Antoniades C. et al, (2012), J Am Coll Cardiol, 59, 60 - 70

Systemic and vascular oxidation limits the efficacy of oral tetrahydrobiopterin treatment in patients with coronary artery disease

Cunnington C. et al, (2012), Circulation, 125, 1356 - 1366

Statins and vein graft failure in coronary bypass surgery

Margaritis M. et al, (2012), Current Opinion in Pharmacology, 12, 172 - 180

Early diagnosis of perioperative myocardial infarction after coronary bypass grafting: a study using biomarkers and cardiac magnetic resonance imaging.

Lim CCS. et al, (2011), Ann Thorac Surg, 92, 2046 - 2053

Induction of vascular GTP-cyclohydrolase I and endogenous tetrahydrobiopterin synthesis protect against inflammation-induced endothelial dysfunction in human atherosclerosis.

Antoniades C. et al, (2011), Circulation, 124, 1860 - 1870

Induction of vascular GTP-cyclohydrolase i and endogenous tetrahydrobiopterin synthesis protect against inflammation-induced endothelial dysfunction in human atherosclerosis

Antoniades C. et al, (2011), Circulation, 124, 1860 - 1870

Effects of the Ala379Val polymorphism of lipoprotein-associated phospholipase A2 on thrombosis and inflammation in hypertensive patients.

Kardara D. et al, (2011), Int J Cardiol, 152, 247 - 249

Do endothelial progenitor cells modify our strategy to treat risk factors?

Tousoulis D. et al, (2011), Int J Cardiol, 152, 95 - 97

C-reactive protein and endothelial dysfunction: gazing at the coronaries.

Tousoulis D. et al, (2011), Int J Cardiol, 152, 1 - 3

Atrial sources of reactive oxygen species vary with the duration and substrate of atrial fibrillation: implications for the antiarrhythmic effect of statins.

Reilly SN. et al, (2011), Circulation, 124, 1107 - 1117

Atrial sources of reactive oxygen species vary with the duration and substrate of atrial fibrillation: implications for the antiarrhythmic effect of statins.

Reilly SN. et al, (2011), Circulation, 124, 1107 - 1117

Methionine-induced homocysteinemia impairs endothelial function in hypertensives: the role of asymmetrical dimethylarginine and antioxidant vitamins.

Tousoulis D. et al, (2011), Am J Hypertens, 24, 936 - 942

Rapid, direct effects of statin treatment on arterial redox state and nitric oxide bioavailability in human atherosclerosis via tetrahydrobiopterin-mediated endothelial nitric oxide synthase coupling.

Antoniades C. et al, (2011), Circulation, 124, 335 - 345

Rapid, direct effects of statin treatment on arterial redox state and nitric oxide bioavailability in human atherosclerosis via tetrahydrobiopterin- mediated endothelial nitric oxide synthase coupling

Antoniades C. et al, (2011), Circulation, 124, 335 - 345

Combined effects of atorvastatin and metformin on glucose-induced variations of inflammatory process in patients with diabetes mellitus.

Tousoulis D. et al, (2011), Int J Cardiol, 149, 46 - 49

Adiponectin as a regulator of vascular redox state: therapeutic implications.

Antonopoulos AS. et al, (2011), Recent Pat Cardiovasc Drug Discov, 6, 78 - 88

Exercise duration as a determinant of vascular function and antioxidant balance in patients with coronary artery disease.

Michaelides AP. et al, (2011), Heart, 97, 832 - 837

Bypass surgery in a patient with single coronary artery.

Koumallos N. et al, (2011), Eur J Cardiothorac Surg, 39

Oxidative stress in the vascular wall: a useful physiological process or a therapeutic target in vascular disease?

Antoniades C., (2011), Recent Pat Cardiovasc Drug Discov, 6, 74 - 77

The role of endothelial progenitor cells in vascular repair after arterial injury and atherosclerotic plaque development.

Briasoulis A. et al, (2011), Cardiovasc Ther, 29, 125 - 139

With the "universal definition," measurement of creatine kinase-myocardial band rather than troponin allows more accurate diagnosis of periprocedural necrosis and infarction after coronary intervention.

Lim CCS. et al, (2011), J Am Coll Cardiol, 57, 653 - 661

The significance of right-sided chest leads in exercise testing for the detection of right ventricular dysfunction post myocardial infarction of the inferior wall.

Michaelides A. et al, (2011), Int J Cardiol, 146, 330 - 333

Novel methodology for the detection of exercise-induced myocardial wall motion abnormalities by surface electrocardiogram during exercise test.

Michaelides AP. et al, (2011), J Electrocardiol, 44, 377 - 382

Effects of the Ala379Val polymorphism of lipoprotein-associated phospholipase A2 on thrombosis and inflammation in hypertensive patients

Kardara D. et al, (2011), International Journal of Cardiology

Comparative effects of rosuvastatin and allopurinol on circulating levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in patients with chronic heart failure.

Tousoulis D. et al, (2010), Int J Cardiol, 145, 438 - 443

Platelet activation in atherogenesis associated with low-grade inflammation.

Antoniades C. et al, (2010), Inflamm Allergy Drug Targets, 9, 334 - 345

Letter by Antoniades et al regarding article, "Uncoupled cardiac nitric oxide synthase mediates diastolic dysfunction".

Antoniades C. et al, (2010), Circulation, 122

ST-Segment Depression in Hyperventilation Indicates a False Positive Exercise Test in Patients with Mitral Valve Prolapse.

Michaelides AP. et al, (2010), Cardiol Res Pract, 2010

Gene therapy for dysfunctional endothelium: is dimethylarginine dimethylaminohydrolase-2 a therapeutic target?

Tousoulis D. et al, (2010), Int J Cardiol, 144, 173 - 174

Nanoparticles: a promising therapeutic approach in atherosclerosis.

Antoniades C. et al, (2010), Curr Drug Deliv, 7, 303 - 311

Preoperative atorvastatin treatment in CABG patients rapidly improves vein graft redox state by inhibition of Rac1 and NADPH-oxidase activity.

Antoniades C. et al, (2010), Circulation, 122, S66 - S73

A 31 year old woman with essential hypertension grade III and branch retinal vein occlusion with homozygous C677T MTHFR hyperhomocysteinemia and high Lp(a) levels.

Katsi V. et al, (2010), Int J Cardiol, 143, e42 - e44

Impact of 6 weeks of treatment with low-dose metformin and atorvastatin on glucose-induced changes of endothelial function in adults with newly diagnosed type 2 diabetes mellitus: A single-blind study.

Tousoulis D. et al, (2010), Clin Ther, 32, 1720 - 1728

Rosuvastatin but not ezetimibe improves endothelial function in patients with heart failure, by mechanisms independent of lipid lowering.

Gounari P. et al, (2010), Int J Cardiol, 142, 87 - 91

The activation of endothelin-1 pathway during methionine-induced homocysteinemia mediates endothelial dysfunction in hypertensive individuals.

Tousoulis D. et al, (2010), J Hypertens, 28, 925 - 930

Right-sided chest leads in exercise testing for detection of coronary restenosis.

Michaelides AP. et al, (2010), Clin Cardiol, 33, 236 - 240

Role of depression in heart failure--choosing the right antidepressive treatment.

Tousoulis D. et al, (2010), Int J Cardiol, 140, 12 - 18

Genetic polymorphism on type 2 receptor of angiotensin II, modifies cardiovascular risk and systemic inflammation in hypertensive males.

Tousoulis D. et al, (2010), Am J Hypertens, 23, 237 - 242

Acute effects of different types of oil consumption on endothelial function, oxidative stress status and vascular inflammation in healthy volunteers.

Tousoulis D. et al, (2010), Br J Nutr, 103, 43 - 49

Inflammatory and thrombotic processes are associated with vascular dysfunction in children with familial hypercholesterolemia.

Charakida M. et al, (2009), Atherosclerosis, 204, 532 - 537

Antidepressive treatment as a modulator of inflammatory process in patients with heart failure: effects on proinflammatory cytokines and acute phase protein levels.

Tousoulis D. et al, (2009), Int J Cardiol, 134, 238 - 243

The impact of ezetimibe and high-dose of statin treatment on LDL levels in patients with heterozygous familial hypercholesterolemia.

Pitsavos C. et al, (2009), Int J Cardiol, 134, 280 - 281

MTHFR 677 C>T Polymorphism reveals functional importance for 5-methyltetrahydrofolate, not homocysteine, in regulation of vascular redox state and endothelial function in human atherosclerosis.

Antoniades C. et al, (2009), Circulation, 119, 2507 - 2515

Adiponectin: from obesity to cardiovascular disease.

Antoniades C. et al, (2009), Obes Rev, 10, 269 - 279

Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endothelial function in human atherosclerosis.

Antoniades C. et al, (2009), Eur Heart J, 30, 1142 - 1150

Effective platelet inhibition by aspirin and clopidogrel: where are we now?

Tousoulis D. et al, (2009), Heart, 95, 850 - 858

Adiponectin: From obesity to cardiovascular disease: Etiology and Pathophysiology

Antoniades C. et al, (2009), Obesity Reviews, 10, 269 - 279

Early initiation of low-dose atorvastatin treatment after an acute ST-elevated myocardial infarction, decreases inflammatory process and prevents endothelial injury and activation.

Stefanadi E. et al, (2009), Int J Cardiol, 133, 266 - 268

ST segment "hump" during exercise testing and the risk of sudden cardiac death in patients with hypertrophic cardiomyopathy.

Michaelides AP. et al, (2009), Ann Noninvasive Electrocardiol, 14, 158 - 164

Relationship between the pharmacokinetics of levosimendan and its effects on cardiovascular system.

Antoniades C. et al, (2009), Curr Drug Metab, 10, 95 - 103

Relation of preoperative radial artery flow-mediated dilatation to nitric oxide bioavailability in radial artery grafts used in off-pump coronary artery bypass grafting.

Antoniades C. et al, (2009), Am J Cardiol, 103, 216 - 220

Electrocardiographic criteria for detecting coronary artery disease in hypertensive patients with ST-segment changes during exercise testing.

Michaelides AP. et al, (2009), J Electrocardiol, 42, 405 - 409

Role of inflammation and oxidative stress in endothelial progenitor cell function and mobilization: therapeutic implications for cardiovascular diseases.

Tousoulis D. et al, (2008), Atherosclerosis, 201, 236 - 247

Beneficial effects of statin treatment after myocardial infarction: Is progenitor cell mobilization the missing link?

Tousoulis D. et al, (2008), Int J Cardiol, 130, 301 - 303

Common community infections and the risk for coronary artery disease and acute myocardial infarction: evidence for chronic over-expression of tumor necrosis factor alpha and vascular cells adhesion molecule-1.

Nikolopoulou A. et al, (2008), Int J Cardiol, 130, 246 - 250

Candidate gene polymorphisms and the 9p21 locus in acute coronary syndromes.

Tousoulis D. et al, (2008), Trends Mol Med, 14, 441 - 449

Correlation of modification of heart rate recovery with adaptation to myocardial ischemia in a model of sequential exercise testings.

Michaelides AP. et al, (2008), Ann Noninvasive Electrocardiol, 13, 364 - 370

Common genetic polymorphisms and haplotypes of fibrinogen alpha, beta, and gamma chains affect fibrinogen levels and the response to proinflammatory stimulation in myocardial infarction survivors: the AIRGENE study.

Jacquemin B. et al, (2008), J Am Coll Cardiol, 52, 941 - 952

Smoking in Asians: it doesn't stop at vascular endothelium.

Antoniades C. et al, (2008), Int J Cardiol, 128, 151 - 153

Selective serotonin reuptake inhibitors modify the effect of beta-blockers on long-term survival of patients with end-stage heart failure and major depression.

Tousoulis D. et al, (2008), J Card Fail, 14, 456 - 464

Acute effects of different alcoholic beverages on vascular endothelium, inflammatory markers and thrombosis fibrinolysis system.

Tousoulis D. et al, (2008), Clin Nutr, 27, 594 - 600

GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function.

Antoniades C. et al, (2008), J Am Coll Cardiol, 52, 158 - 165

Valve replacement for Brucella endocarditis: two case reports.

Koumallos N. et al, (2008), Int J Cardiol, 127, e83 - e85

Short-term treatment with L-arginine prevents the smoking-induced impairment of endothelial function and vascular elastic properties in young individuals.

Siasos G. et al, (2008), Int J Cardiol, 126, 394 - 399

Methionine-loading rapidly impairs endothelial function, by mechanisms independent of endothelin-1: evidence for an association of fasting total homocysteine with plasma endothelin-1 levels.

Tousoulis D. et al, (2008), J Am Coll Nutr, 27, 379 - 386

Heart regeneration: what cells to use and how?

Tousoulis D. et al, (2008), Curr Opin Pharmacol, 8, 211 - 218

Effects of irbesartan and perindopril on forearm reactive hyperemia and inflammatory process, in normotensive patients with coronary artery disease.

Tousoulis D. et al, (2008), Int J Cardiol, 124, 127 - 129

Effects of ramipril on endothelial function and the expression of proinflammatory cytokines and adhesion molecules in young normotensive subjects with successfully repaired coarctation of aorta: a randomized cross-over study.

Brili S. et al, (2008), J Am Coll Cardiol, 51, 742 - 749

Statins ameliorate atherosclerosis induced by inhibition of nitric oxide synthase: another novel vascular protective mechanism?

Tousoulis D. et al, (2008), Int J Cardiol, 123, 91 - 93

New biochemical markers in acute coronary syndromes.

Tousoulis D. et al, (2008), Curr Med Chem, 15, 1288 - 1296

Clinical genetics of functionally mild non-coding GTP cyclohydrolase 1 (GCH1) polymorphisms modulating pain and cardiovascular risk.

Doehring A. et al, (2008), Mutat Res, 659, 195 - 201

Altered plasma versus vascular biopterins in human atherosclerosis reveal relationships between endothelial nitric oxide synthase coupling, endothelial function, and inflammation.

Antoniades C. et al, (2007), Circulation, 116, 2851 - 2859

Evidence that non-lipid cardiovascular risk factors are associated with high prevalence of coronary artery disease in patients with heterozygous familial hypercholesterolemia or familial combined hyperlipidemia.

Skoumas I. et al, (2007), Int J Cardiol, 121, 178 - 183

Diabetes mellitus as a predictor for radial artery vasoreactivity in patients undergoing coronary artery bypass grafting.

Choudhary BP. et al, (2007), J Am Coll Cardiol, 50, 1047 - 1053

Effects of insulin dependence on inflammatory process, thrombotic mechanisms and endothelial function, in patients with type 2 diabetes mellitus and coronary atherosclerosis.

Antoniades C. et al, (2007), Clin Cardiol, 30, 295 - 300

Nitric oxide-releasing aspirin: will it say NO to atherothrombosis?

Antoniades C. et al, (2007), Int J Cardiol, 118, 170 - 172

Mechanisms of disease: L-arginine in coronary atherosclerosis--a clinical perspective.

Tousoulis D. et al, (2007), Nat Clin Pract Cardiovasc Med, 4, 274 - 283

Global improvement of vascular function and redox state with low-dose folic acid: implications for folate therapy in patients with coronary artery disease.

Shirodaria C. et al, (2007), Circulation, 115, 2262 - 2270

Levosimendan: beyond its simple inotropic effect in heart failure.

Antoniades C. et al, (2007), Pharmacol Ther, 114, 184 - 197

L-Arginine, the substrate for NO synthesis: an alternative treatment for premature atherosclerosis?

Siasos G. et al, (2007), Int J Cardiol, 116, 300 - 308

Effects of endothelial nitric oxide synthase gene polymorphisms on oxidative stress, inflammatory status, and coronary atherosclerosis: an example of a transient phenotype.

Antoniades C. et al, (2007), J Am Coll Cardiol, 49

Multi-modal magnetic resonance imaging quantifies atherosclerosis and vascular dysfunction in patients with type 2 diabetes mellitus.

Lee JMS. et al, (2007), Diab Vasc Dis Res, 4, 44 - 48

Differences in inflammatory and thrombotic markers between unstable angina and acute myocardial infarction.

Tousoulis D. et al, (2007), Int J Cardiol, 115, 203 - 207

Effects of atorvastatin and vitamin C on forearm hyperaemic blood flow, asymmentrical dimethylarginine levels and the inflammatory process in patients with type 2 diabetes mellitus.

Tousoulis D. et al, (2007), Heart, 93, 244 - 246

Cold pressor test as a marker for the detection of early stage coronary atherosclerosis.

Tousoulis D. et al, (2007), Int J Cardiol, 115, 120 - 122

Homocysteine lowering: any use in atherosclerosis?

Antoniades C. et al, (2007), Hellenic J Cardiol, 48, 249 - 251

Potential role of endothelial progenitor cells in the pathophysiology of heart failure: clinical implications and perspectives.

Andreou I. et al, (2006), Atherosclerosis, 189, 247 - 254

Long-term effects of levosimendan infusion on inflammatory processes and sFas in patients with severe heart failure.

Trikas A. et al, (2006), Eur J Heart Fail, 8, 804 - 809

Acute improvement of aortic mechanics following hemodialysis in patients with chronic renal failure.

Soubassi LP. et al, (2006), Clin Cardiol, 29, 506 - 510

Asymmetrical dimethylarginine regulates endothelial function in methionine-induced but not in chronic homocystinemia in humans: effect of oxidative stress and proinflammatory cytokines.

Antoniades C. et al, (2006), Am J Clin Nutr, 84, 781 - 788

5-methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels: effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling.

Antoniades C. et al, (2006), Circulation, 114, 1193 - 1201

Pro-inflammatory cytokines in acute coronary syndromes: from bench to bedside.

Tousoulis D. et al, (2006), Cytokine Growth Factor Rev, 17, 225 - 233

Levosimendan: a novel agent in heart failure.

Koumallos N. et al, (2006), Recent Pat Cardiovasc Drug Discov, 1, 185 - 191

Genetic polymorphisms of platelet glycoprotein Ia and the risk for premature myocardial infarction: effects on the release of sCD40L during the acute phase of premature myocardial infarction.

Antoniades C. et al, (2006), J Am Coll Cardiol, 47, 1959 - 1966

The impact of early administration of low-dose atorvastatin treatment on inflammatory process, in patients with unstable angina and low cholesterol level.

Tousoulis D. et al, (2006), Int J Cardiol, 109, 48 - 52

Statins and antioxidant vitamins: should co-administration be avoided?

Tousoulis D. et al, (2006), J Am Coll Cardiol, 47

Genetic polymorphisms G894T on the eNOS gene is associated with endothelial function and vWF levels in premature myocardial infarction survivors.

Antoniades C. et al, (2006), Int J Cardiol, 107, 95 - 100

Effects of early administration of atorvastatin treatment on thrombotic process in normocholesterolemic patients with unstable angina.

Tousoulis D. et al, (2006), Int J Cardiol, 106, 333 - 337

Effects of combined administration of low dose atorvastatin and vitamin E on inflammatory markers and endothelial function in patients with heart failure.

Tousoulis D. et al, (2005), Eur J Heart Fail, 7, 1126 - 1132

Endothelial dysfunction and inflammatory process in transfusion-dependent patients with beta-thalassemia major.

Aggeli C. et al, (2005), Int J Cardiol, 105, 80 - 84

Letter regarding article by Becker et al, "Hyperhomocysteinemia, a cardiac metabolic disease: role of nitric oxide and the p22phox subunit of NADPH oxidase".

Antoniades C. et al, (2005), Circulation, 112

Effects of vitamin C on intracoronary L-arginine dependent coronary vasodilatation in patients with stable angina.

Tousoulis D. et al, (2005), Heart, 91, 1319 - 1323

Genetic polymorphism on endothelial nitric oxide synthase affects endothelial activation and inflammatory response during the acute phase of myocardial infarction.

Antoniades C. et al, (2005), J Am Coll Cardiol, 46, 1101 - 1109

Combined effects of smoking and hypercholesterolemia on inflammatory process, thrombosis/fibrinolysis system, and forearm hyperemic response.

Antoniades C. et al, (2004), Am J Cardiol, 94, 1181 - 1184

Evidence for association between endothelial nitric oxide synthase gene polymorphism (G894T) and inflammatory markers: the ATTICA study.

Chrysohoou C. et al, (2004), Am Heart J, 148, 733 - 738

Vascular endothelium and inflammatory process, in patients with combined Type 2 diabetes mellitus and coronary atherosclerosis: the effects of vitamin C.

Antoniades C. et al, (2004), Diabet Med, 21, 552 - 558

Effects of levosimendan on circulating pro-inflammatory cytokines and soluble apoptosis mediators in patients with decompensated advanced heart failure.

Parissis JT. et al, (2004), Am J Cardiol, 93, 1309 - 1312

Endothelial function and proinflammatory cytokines in patients with ischemic heart disease and dilated cardiomyopathy.

Tentolouris C. et al, (2004), Int J Cardiol, 94, 301 - 305

Oxidative stress, antioxidant vitamins, and atherosclerosis. From basic research to clinical practice.

Antoniades C. et al, (2003), Herz, 28, 628 - 638

Vitamin C affects thrombosis/ fibrinolysis system and reactive hyperemia in patients with type 2 diabetes and coronary artery disease.

Tousoulis D. et al, (2003), Diabetes Care, 26, 2749 - 2753

Effects of combined administration of vitamins C and E on reactive hyperemia and inflammatory process in chronic smokers.

Tousoulis D. et al, (2003), Atherosclerosis, 170, 261 - 267

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Charalambos Antoniades

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