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Anna Veprik

Novo Nordisk Postdoctoral Research Fellow (2016-2019)

  • Project: Investigating lipid metabolism in islet a-cells and gut L-cells, as a nutrient sensing mechanism controlling hormone secretion

Biography

Anna was awarded the Novo Nordisk Postdoctoral Fellowship in 2016, working with Dr James Cantley and Professor Heidi de Wet in DPAG. During her fellowship, she broadened the understanding of the connection between nutritional status of the pancreatic α and gut enteroendocrine L-cells and their ability to respond to metabolic stimuli. This work combined the establishment of genetically and pharmacologically modified organisms, primary ex vivo models and cell lines. It uncovered the central role played by Acetyl-CoA-Carboxylase 1 (ACC1) in the regulation of endocrine cell growth and hormone secretion.

Following her fellowship, Anna joined the Novo Nordisk Research Centre Oxford (NNRCO) as a Post-Doctoral Research Scientist in the Department of Discovery Biology and Pharmacology. She is leading the development of high-throughput screening platforms for unbiased target identification in the liver. In her new role, she pursuing further her long standing interest in the multi-organ pathophysiology of metabolic diseases.