Ph.D., M.Sc., B.Sc(Hons)
My current research involves the identification and functional characterization of a class of polyvalent chemokine-binding tick salivary peptides called evasins, each of which exerts its anti-inflammatory properties by neutralizing and disrupting specific chemokine networks. In particular, we focus on evasins that target the CXC subfamily chemokines, many of which have known association with cardiac inflammatory diseases such as myocarditis. Using a short-term peritonitis model, we hope to verify the biological function of selected evasins in vivo and validate their potential as anti-inflammatory therapeutics. My other research project concerns with the proprotein convertase FURIN, the inhibition of which reduces fibrillar collagen predisposition in an in-vitro fibrosis model ('scar-in-a-jar' assay) via its specific cleavage of various profibrotic peptides.
A knottin scaffold directs the CXC-chemokine-binding specificity of tick evasins.
Lee AW. et al, (2019), J Biol Chem, 294, 11199 - 11212
Functional inactivation of the genome-wide association study obesity gene neuronal growth regulator 1 in mice causes a body mass phenotype.
Lee AWS. et al, (2012), PLoS One, 7
Use of mouse models in studying type 2 diabetes mellitus.
Lee AWS. and Cox RD., (2011), Expert Rev Mol Med, 13
A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene.
Church C. et al, (2009), PLoS Genet, 5