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Alessandro Cavallo

Postdoctoral Research Scientist

My research focusses on the transcriptional regulation of endothelial-to-haematopoietic transition, the developmental process by which haematopoietic stem cells are formed in the embryo. I am modelling this process "in a dish", by differentiating human induced pluripotent stem cells (iPSCs) in vitro. To identify the key factors which are important for generating blood and immune cells in vitro, I am using single cell multi-omic and other epigenetic profiling approaches, as well as gene regulatory network analysis. Future potential applications of my research include blood (stem) cell generation for regenerative medicine and cell therapy applications.

Prior to my current position, I completed a DPhil here at Oxford in Prof. Marella de Bruijn's group.

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