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Alba Rodriguez-Meira

DPhil Student

I am a DPhil Student supervised by Prof. Adam Mead and Prof. Sten Eirik Jacobsen. A molecular biologist by background with a deep interest in next generation sequencing, my research focuses on the application of single genomics to unravel the molecular heterogeneity of the stem cell compartment in patients with myeloid malignancies.

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Recent Publications

Rodriguez-Meira, A. Buck, G. Clark, SA. Povinelli, B.J. Alcolea, V. Louka, E. McGowan, S. Hamblin, A. Sousos, N. Barkas, N. Giustacchini, A. Psaila, B. Jacobsen, S. E. W.  Thongjuea, S. Mead, A. J. Unraveling intratumoral heterogeneity through high-sensitivity single-cell mutational analysis and parallel RNA-sequencing. BioRxiv.

Povinelli, B.J.*, A. Rodriguez-Meira*, and A.J. Mead, Single cell analysis of normal and leukemic hematopoiesis. Mol Aspects Med, 2018. 59(1872-9452 (Electronic)): p. 85-94. *These authors contributed equally.

Giustacchini, A.* Thongjuea, S.* Barkas, N. Woll, P. S. Povinelli, B. J. Booth, C. A. G. Sopp, P. Norfo, R. Rodriguez-Meira, A. Ashley, N. Jamieson, L. Vyas, P. Anderson, K. Segerstolpe, A. Qian, H. Olsson-Stromberg, U. Mustjoki, S. Sandberg, R. Jacobsen, S. E. W.* Mead, A. J.*, Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia. Nat Med, 2017. 23(6): p. 692-702. *These authors contributed equally.

Nguyen, V. T. Barozzi, I. Faronato, M. Lombardo, Y. Steel, J. H. Patel, N. Darbre, P. Castellano, L. Gyorffy, B. Woodley, L. Meira, A. Patten, D. K. Vircillo, V. Periyasamy, M. Ali, S. Frige, G. Minucci, S. Coombes, R. C. Magnani, L., Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion. Nat Commun, 2015. 6(2041-1723 (Electronic)): p. 10044.

Vicente-Dueñas, C. Hauer, J. Ruiz-Roca, L. Ingenhag, D. Rodríguez-Meira, A. Auer, F. Borkhardt, A. Sánchez-García, I, Tumoral stem cell reprogramming as a driver of cancer: Theory, biological models, implications in cancer therapy. Seminars in Cancer Biology, 2015. 32(Supplement C): p. 3-9.