Professor of Stroke Medicine
- Pro-Vice-Chancellor (Head of Brexit Strategy)
Acute stroke and Neuroprotection
Prof Alastair Buchan heads the Laboratory of Cerebral Ischaemia whose aim is to identify novel neuroprotective strategies that may be used for the treatment or prevention of an acute stroke. We conduct preclinical studies on putative neuroprotectants in models of stroke, while running human studies to identify potential targets for treatment strategies and markers for monitoring patients. We take a multimodal approach that involves aspects of cell and molecular biology, physiology, pharmacology, in vivo imaging, surgery and clinical medicine. Our interests currently lie in many exciting avenues of stroke research. We are identifying and targeting novel neuroprotective pathways following brain ischaemia such as the oxygen sensing mechanism, hypoxia inducible factor (HIF). We are also using proteomic and metabolomic techniques to identify new biomarkers for stroke. Other avenues of research include investigating neurovascular coupling following stroke, exploring pericyte control of capillary blood flow as well as attempting to improve the efficacy of the only approved treatment for acute stroke, recombinant tissue plasminogen activator (rtPA).
Investigation of the novel mTOR inhibitor AZD2014 in neuronal ischemia.
Hadley G. et al, (2019), Neurosci Lett, 706, 223 - 230
Structural Transformation to Attain Responsible BIOSciences (STARBIOS2): Protocol for a Horizon 2020 Funded European Multicenter Project to Promote Responsible Research and Innovation.
Colizzi V. et al, (2019), JMIR Res Protoc, 8
The effect of rapamycin treatment on cerebral ischemia: A systematic review and meta-analysis of animal model studies.
Beard DJ. et al, (2019), Int J Stroke, 14, 137 - 145
New indicators and indexes for benchmarking university-industry-government innovation in medical and life science clusters: results from the European FP7 Regions of Knowledge HealthTIES project.
Edmunds LD. et al, (2019), Health Res Policy Syst, 17
Rapamycin in ischemic stroke: Old drug, new tricks?
Hadley G. et al, (2019), J Cereb Blood Flow Metab, 39, 20 - 35