Diabetes Trials Unit
The Diabetes Trials Unit (DTU) is a UKCRC accredited clinical trials unit specialising in performing local, national and multinational clinical trials related to treating and managing diabetes and other cardiometabolic and related conditions. We work collaboratively with researchers and organisations to support trials and other studies.
Director
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Amanda Adler
Professor of Diabetic Medicine and Health Policy
What's new
Hydroxychloroquine provides moderate COVID-19 prevention
16 September 2024
COPCOV, the world’s largest COVID-19 chemoprevention study, published results today showing that hydroxychloroquine (HCQ) has a moderate benefit in preventing COVID-19. The COPCOV trial was led globally by the Mahidol Oxford Tropical Medicine Research Unit (MORU), Thailand. The Diabetes Trials Unit (DTU) was the UK coordinating centre for the trial, helped develop the protocol, and was responsible for managing UK sites, approvals and procedures.
Patients receiving steroids are more than twice as likely to develop diabetes, UK study has found
10 September 2024
Patients who are being treated with systemic glucocorticoids are more than twice as likely to develop diabetes as those not receiving the treatment, a new study by researchers at the Radcliffe Department of Medicine’s Diabetes Trial Unit has found.
Early blood glucose control for people with type 2 diabetes is crucial for reducing complications and prolonging life
18 May 2024
Research led by scientists from the Universities of Oxford and Edinburgh has found that early good blood glucose control can minimise the lifetime risk of diabetes-related complications, including heart attacks, kidney failure and vision loss.
The LEGEND-D Trial – which aims to prevent low blood sugar levels in type 1 diabetes – is open to recruitment
16 April 2024
The first participant has completed initial study activities and is now randomised to one of the trial’s arms.
DTU to run clinical trial for Dementias Platform UK in nationwide bid to revolutionise dementia diagnosis using blood tests
4 April 2024
Dementias Platform UK has been awarded over £4 million to carry out countrywide trials to identify accurate and quick blood tests that can diagnose dementia, in a bid to improve management and patient and carer wellbeing. RDM's Diabetes Trials Unit will run the clinical trial component of the challenge.
Latest publications
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The Diabetes Technology Society Error Grid and Trend Accuracy Matrix for Glucose Monitors.
Journal article
Klonoff DC. et al, (2024), J Diabetes Sci Technol
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Inflammatory proteins associated with Alzheimer's disease reduced by a GLP1 receptor agonist: a post hoc analysis of the EXSCEL randomized placebo controlled trial.
Journal article
Koychev I. et al, (2024), Alzheimers Res Ther, 16
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Going beyond randomised controlled trials to assess treatment effect heterogeneity across target populations.
Journal article
Lugo-Palacios DG. et al, (2024), Health Econ
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Evaluation of hydroxychloroquine or chloroquine for the prevention of COVID-19 (COPCOV): A double-blind, randomised, placebo-controlled trial.
Journal article
Schilling WHK. et al, (2024), PLoS Med, 21
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Using QALYs as an outcome for assessing global prediction accuracy in diabetes simulation models
Journal article
DAKIN H. et al, (2024), Medical decision making