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Enhancers regulate the expression of target genes across large genomic distances, but it is unclear how recently discovered topological domains affect this regulation. Reporting in this issue of Developmental Cell, Symmons et al. (2016) show that the endogenous Shh topological domain promotes functional interactions between Shh and its remote enhancer.

Original publication

DOI

10.1016/j.devcel.2016.11.011

Type

Journal article

Journal

Dev Cell

Publication Date

05/12/2016

Volume

39

Pages

523 - 524

Keywords

Enhancer Elements, Genetic, Gene Expression Regulation, Developmental