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PECAM-1, the platelet-endothelial cell adhesion molecule, is expressed on a variety of mature hemopoietic cell types (including neutrophils, monocytes and T cell subsets) and is also present on endothelia. In such cases, this glycoprotein functions as either a homotypic or heterotypic adhesion molecule contributing to cell migration, inflammatory processes and wound healing. We have recently shown that PECAM-1 is expressed on a variety of hemopoietic progenitor cell types and on stromal macrophages from human bone marrow. In this review, we discuss the possible functional significance of this molecule for both hemopoietic cell differentiation and for mature cells.

Original publication




Journal article


Leukemia & lymphoma

Publication Date





229 - 244


MRC Molecular Haematology Unit, John Radcliffe Hospital, Oxford, U.K.


Endothelium, Vascular, Hematopoietic System, Humans, Cell Adhesion Molecules, Antigens, Differentiation, Myelomonocytic, Gene Expression, Amino Acid Sequence, Sequence Homology, Amino Acid, Molecular Sequence Data, Platelet Endothelial Cell Adhesion Molecule-1