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Previous studies have demonstrated that there are circadian rhythms in susceptibility to a range of commonly used cytotoxic drugs. In this study we have compared the pharmacokinetics and myelotoxicity of carboplatin administered at 18.00 and 06.00 in random order in patients with advanced ovarian carcinoma. Carboplatin treatment at 06.00 is associated with significantly greater thrombocytopenia than at 18.00 (platelet nadir 95,000 versus 180,000, p less than 0.05). There was no pharmacokinetic difference in the patients' handling of ultrafilterable platinum therefore it is possible that there is an intrinsic rhythm of susceptibility of bone marrow to carboplatin.

Original publication

DOI

10.1002/hon.2900080108

Type

Journal article

Journal

Hematol Oncol

Publication Date

01/1990

Volume

8

Pages

59 - 63

Keywords

Blood Cell Count, Bone Marrow, Carboplatin, Circadian Rhythm, Female, Hematopoiesis, Humans, Middle Aged, Organoplatinum Compounds, Ovarian Neoplasms