Websites
-
Lab website (www.jdavieslab.com)
Lab website
-
RDM lab website
RDM lab website
Collaborators
-
Douglas Higgs
Emeritus Professor
-
Jim Hughes
Professor of Gene Regulation
James Davies
DPhil, MRCP
Associate Professor of Genomics
- MRC Clinician Scientist
- Honorary Consultant Haematologist
Biography
I am a clinician scientist with a specialist interest in haemopoietic stem cell transplantation, genome editing, genomics and bioinformatics. I studied medicine at Oxford University before going on to complete specialist training in haematology and intensive care medicine in London. I have an MRC Clinician Scientist Fellowship and my group is based at the MRC Weatherall Institute of Molecular Medicine. In addition, I am an honorary consultant haematologist with the allogeneic transplant service in Oxford.
My research focuses on developing novel next generation sequencing-based methods for interrogating how the genome functions and leveraging this to develop methods of genome editing bone marrow derived stem cells. I have a particular interest in developing methods that allow the physical structure of DNA in the nucleus to be defined. The way in which chromatin is folded is one of the key determinants of gene expression. We leverage our understanding of how the genome functions to develop novel strategies of editing blood and bone marrow derived cells to treat human disease. In particular, we are interested in using our expertise in developing high throughput sequencing assays and bioinformatics to develop new ways of defining the off-target effects caused by genome editing.
Key publications
-
Journal article
Hua P. et al, (2021), Nature, 595, 125 - 129
-
Journal article
Downes DJ. et al, (2021), Nat Genet, 53, 1606 - 1615
-
Journal article
Badat M. et al, (2023), Nat Commun, 14
-
Journal article
Aljahani A. et al, (2022), Nat Commun, 13
-
Journal article
Davies JOJ. et al, (2017), Nat Methods, 14, 125 - 134
Recent publications
-
Journal article
Hughes JR. and Davies JOJ., (2024), Nat Genet
-
Journal article
Maresca M. et al, (2023), EMBO J
ORCID
0000-0002-4108-4357