Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

The study, which tracked volunteers for up to 44 years, showed that the benefits of early intensive blood glucose control can persist for decades.

Close up of hands showing black lancet pressing  against finger, with glucose monitor in the background.

These results are from the UK Prospective Diabetes Study (UKPDS), one of the longest ever studies of type 2 diabetes. Led by researchers from the Universities of Oxford and Edinburgh, new data from the UKPDS have shown that the problems experienced by people with type 2 diabetes, including heart attacks, kidney failure and vision loss, are not inevitable, and that the benefits of early good blood glucose control can persist for decades.

Starting in 1977, the UKPDS randomly allocated people with newly-diagnosed type 2 diabetes to an intensive blood glucose control strategy with sulfonylureas, insulin or metformin, or to a conventional blood glucose control strategy, primarily with diet. The 20-year trial results, published in 1998, showed that good blood glucose control reduced the risk of diabetic complications. Worldwide, UKPDS changed guidelines to recommend intensive blood glucose control for everyone with type 2 diabetes. This meant that the therapies and blood glucose levels in the two UKPDS groups rapidly became similar. Despite this convergence, the 10-year post-study follow-up analysis, published in 2008, showed the reduction in the risk of diabetic complications continued for up to 30 years, a legacy effect of early intensive blood glucose control.

The new results show that the legacy effects of implementing intensive blood glucose control straight after diagnosis continue to persist for up to 44 years. Early intensive blood glucose control with insulin injections or sulfonylurea tablets led to 11% fewer deaths and 26% fewer diabetic complications such as kidney failure and vision loss. Early intensive blood glucose control with metformin led to 31% fewer heart attacks and 25% fewer deaths.

Professor Rury Holman, the founding Director of the University of Oxford Diabetes Trials Unit and Chief Investigator of the UKPDS, said ‘These remarkable findings emphasise the critical importance of detecting and treating type 2 diabetes intensively at the earliest possible opportunity.’

Professor Holman, will be presenting these findings at the 58th European Association for the Study of Diabetes (EASD0 meeting in Stockholm, Sweden on Wednesday 21 September 2022.

 

This shows that treating type 2 diabetes early and thoroughly is crucial. Playing catch-up with blood glucose control is not sufficient. - Professor Amanda Adler, Diabetes Trial Unit Director and UKPDS Clinical Epidemiologist

 

Professor Philip Clarke, Director of the University of Oxford Health Economics Research Centre, said ‘A major life-time benefit is the increase life-expectancy by around 1–2 years for those allocated to intensive blood glucose control. The reduced rate of many diabetes-related complications will have a positive impact on overall quality of life’.

Dr Will Whiteley, Reader in Neurology at the University of Edinburgh Centre for Clinical Brain Sciences, and Senior Research Fellow at the University of Oxford MRC Centre for Population Health said ‘Following up people from the UKPDS for up to 44 years was possible only with the rich linked NHS data sources across UK nations. This meant we could study the effects of treatments given in midlife on diseases of ageing, such as dementia.'

We want to hear about your news!

Publishing a paper? Just won an award? Get in touch with communications@rdm.ox.ac.uk

 

Similar stories

Anjali Kusumbe receives the RMS Life Sciences Medal

The Royal Microscopical Society awards celebrate the best in microscopy, recognising those making a special contribution to microscopy, cytometry and imaging.

Enterprise Associate Interview with Dr Shilpa Nagarajan

Dr Shilpa Nagarajan is one of the MPLS Enterprise and Innovation Fellows for 2022-23.

The Gene Therapists Headline at Glastonbury 2022

Rosie Munday writes about her experience taking science to the masses at the Glastonbury Festival.

Wellcome Trust funding success for Jim Hughes and James Davies

£3.6 million in funding awarded by the Wellcome Trust to combine cutting-edge 3D genome technologies with machine learning approaches to decipher the role of the non-coding genome in disease.