- Higgs Group: Laboratory of Gene Regulation Research Group
I use molecular techniques to study the three-dimensional folding of the genome, and how this relates to gene expression. I'm particularly interested in enhancers, genomic regions that control how and when cells activate specific sets of genes.
Complex multi-enhancer contacts captured by genome architecture mapping.
Beagrie RA. et al, (2017), Nature, 543, 519 - 524
Examining Topological Domain Influence on Enhancer Function.
Beagrie RA. and Pombo A., (2016), Dev Cell, 39, 523 - 524
Gene activation by metazoan enhancers: Diverse mechanisms stimulate distinct steps of transcription.
Beagrie RA. and Pombo A., (2016), Bioessays, 38, 881 - 893