Research in the Investigative Medicine Division

Buchan Group: Laboratory of Cerebral Ischemia

The Laboratory of Cerebral Ischemia is a pre-clinical research group aiming to discover both the mechanisms which underlie cell death in stroke and to develop novel strategies to reduce this.

Buchan Group: Responsible Research and Innovation

We are focusing on how to make research and innovation relevant to society, sustainable and fair for everyone.

Multi-dimensional Innate and Adaptive lmmune responses

We focus on gaining a better understanding of the mechanisms that control the cell-cell interplay required for optimal expansion and activation of tumour-specific T cell populations and to apply this knowledge to the development of better treatment strategies in cancer patients.

Davis Group: T-cell Biology

We are interested in how lymphocytes decide to mount immune responses against, for example, tumours. This involves trying to understanding how leukocyte receptors, such as the T-cell receptor and immune checkpoints, are triggered.

Drakesmith Group: Iron and Immunity

We are investigating how iron and anaemia influence immunity and infectious diseases. Our research inspires treatments that control iron physiology to benefit the host at the expense of pathogens.

Dong Group: Human T cell responses against Viruses & Cancer

Our group focuses on determining the factors which affect T cells both in the control of viral infection and in the development of cancer.

Eggeling Group

We apply and optimize advanced optical microscopy techniques, such as super-resolution STED microscopy, to decipher molecular dynamics in an unprecedented way. Our main focus is molecular plasma membrane organization, especially following immune responses.

Jackson Group: Lymphatic Trafficking Research Group

We focus on the mechanisms controlling the migration of leucocytes and tumour cells via lymph in health and disease.

Newbold Group: Molecular Parasitology

Our group's interests centre on the role of multi-gene families in malaria in pathogenesis, immune evasion and their evolution.

Ogg Group: Cutaneous Immunology Group

The aim of the group is to understand, at the molecular and cellular level, the role of human cutaneous immune responses in mechanisms of disease, treatment and vaccination. As well as contributing to an understanding of disease pathogenesis, we aim to translate our findings to changes in clinical practice.

Rehwinkel Group: Nucleic Acid Sensing

Townsend Group: Molecular Immunology

Scanning electron microscopy (SEM) image of bacteria in the mouse colon

Simmons Group: Intestinal Immunology Lab

We use state-of the-art molecular and computational approaches to understand mechanisms of intestinal immunity and how those go wrong in the inflammatory bowel diseases, Crohn’s disease and Ulcerative Colitis.

Koohy Group: Machine Learning and Integrative Approaches in Immunology

We would like to understand the functional and molecular mechanisms of the immune system in various immunologically important conditions such as cancer, infection, autoimmune disease as well as ageing. We have a special interest in computational cancer immunotherapy such as antigen presentation, neo-antigen identification and T cell recognition of neo-antigens as well as interrogating the immune response to personalized vaccines from neo-antigens.