Research in the Investigative Medicine Division

Buchan Group: Laboratory of Cerebral Ischemia

The Laboratory of Cerebral Ischemia is a pre-clinical research group aiming to discover both the mechanisms which underlie cell death in stroke and to develop novel strategies to reduce this.

Buchan Group: Responsible Research and Innovation

We are focusing on how to make research and innovation relevant to society, sustainable and fair for everyone.

Davis Group: T-cell Biology

We are interested in how lymphocytes decide to mount immune responses against, for example, tumours. This involves trying to understanding how leukocyte receptors, such as the T-cell receptor and immune checkpoints, are triggered.

Drakesmith Group: Iron and Immunity

We are investigating how iron and anaemia influence immunity and infectious diseases. Our research inspires treatments that control iron physiology to benefit the host at the expense of pathogens.

Dong Group: Human T cell responses against Viruses & Cancer

Our group focuses on determining the factors which affect T cells both in the control of viral infection and in the development of cancer.

Eggeling Group

We apply and optimize advanced optical microscopy techniques, such as super-resolution STED microscopy, to decipher molecular dynamics in an unprecedented way. Our main focus is molecular plasma membrane organization, especially following immune responses.

Jackson Group: Lymphatic Trafficking Research Group

We focus on the mechanisms controlling the migration of leucocytes and tumour cells via lymph in health and disease.

Translational Dermatology Unit

The aim of the group is to understand, at the molecular and cellular level, the role of human cutaneous immune responses in mechanisms of disease, treatment and vaccination. We have a particular focus on T cells which recognise inflammatory lipids presented by CD1a. As well as contributing to an understanding of disease pathogenesis, we aim to translate our findings to changes in clinical practice.

Rehwinkel Group: Nucleic Acid Sensing

Townsend Group: Molecular Immunology

Scanning electron microscopy (SEM) image of bacteria in the mouse colon

Simmons Group: Intestinal Immunity in Health and Disease

We define how the immune system functions in the intestine to promote health. We uncover the immune pathogenesis of intestinal diseases such as inflammatory bowel disease to develop better ways to treat these disorders.

Koohy Group: Machine Learning and Integrative Approaches in Immunology

We would like to understand the functional and molecular mechanisms of the immune system in various immunologically important conditions such as cancer, infection, autoimmune disease as well as ageing. We have a special interest in computational cancer immunotherapy such as antigen presentation, neo-antigen identification and T cell recognition of neo-antigens as well as interrogating the immune response to personalized vaccines from neo-antigens.

Specialized blood vessels (green/yellow) form nurturing niches for osteoprogenitor cells (white) in bone

Kusumbe Lab | Tissue and Tumor Microenvironments

We Study Vascular Changes Over Time With The Aim To Treat Diseases

Composite image showing photos of microfluidic equipment.

Holloway Group: Microfluidic Neurological Models (MNM)

The Oxford MNM group focuses on developing in vitro models for neurological disease. Employing micro-fabrication techniques to define channels and features in cell culture devices at the scale of the cell and below, opens up the opportunity to shape cellular microenvironments to better reflect those found in the body. Our work uses these techniques and induced pluripotent stem cell (iPSC) technologies to create human cell culture models of the brain with the aim of enabling new possibilities to study neurovascular disease and improve drug discovery.

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Research in the Investigative Medicine Division