Contact information
Research groups
DPhil projects available
Assigning Functional Mechanisms to a New Coronary Artery Susceptibility Gene
Gillian Douglas
PhD
University Research Lecturer
Large studies linking common variations to the occurrence of coronary artery disease have enabled us to identify several new genes that may have a causative influence on the susceptibility to developing coronary artery disease. However, for many of these genes the mechanism by which they alter cardiovascular disease pathology is unknown.
Recent publications
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Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression.
Journal article
Douglas G. et al, (2018), Cardiovasc res, 114, 1385 - 1399
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Endothelial Cell Tetrahydrobiopterin Modulates Sensitivity to Ang (Angiotensin) II-Induced Vascular Remodeling, Blood Pressure, and Abdominal Aortic Aneurysm.
Journal article
Chuaiphichai S. et al, (2018), Hypertension, 72, 128 - 138
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THE CORONARY ARTERY DISEASE ASSOCIATED GENE JCAD REGULATES HIPPO SIGNALLING IN ENDOTHELIAL CELLS
Conference paper
Jones PD. et al, (2018), Heart, 104, A71 - A71
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JCAD Gene at the 10p11 Coronary Artery Disease Locus Regulates Hippo Signaling in Endothelial Cells.
Journal article
Jones PD. et al, (2018), Arterioscler thromb vasc biol
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Vascular wall regulator of G-protein signalling-1 (RGS-1) is required for angiotensin II-mediated blood pressure control.
Journal article
Patel J. et al, (2018), Vascul pharmacol