Gillian Douglas

• A Genomic DNA Reporter Screen Identifies Squalene Synthase Inhibitors That Act Cooperatively with Statins to Upregulate the Low-Density Lipoprotein Receptor.

  Journal article

  Kerr AG. et al, (2017), J Pharmacol Exp Ther, 361, 417 - 428

• A key role for tetrahydrobiopterin-dependent endothelial NOS regulation in resistance arteries: studies in endothelial cell tetrahydrobiopterin-deficient mice.

  Journal article

  Chuaiphichai S. et al, (2017), Br J Pharmacol, 174, 657 - 671

• Episomal Nonviral Gene Therapy Vectors Slow Progression of Atherosclerosis in a Model of Familial Hypercholesterolemia.

  Journal article

  Kerr AG. et al, (2016), Mol Ther Nucleic Acids, 5

• Regulation of ventilatory sensitivity and carotid body proliferation in hypoxia by the PHD2/HIF-2 pathway.

  Journal article

  Hodson EJ. et al, (2016), J Physiol, 594, 1179 - 1195

• Episomal Nonviral Gene Therapy Vectors Slow Progression of Atherosclerosis in a Model of Familial Hypercholesterolemia.

  Journal article

  Kerr AG. et al, (2016), Mol Ther Nucleic Acids, 5

• Hydroxychloroquine reduces heart rate by modulating the hyperpolarization-activated current If: Novel electrophysiological insights and therapeutic potential.

  Journal article

  Capel RA. et al, (2015), Heart Rhythm, 12, 2186 - 2194

• RGS-1 REGULATES LEUKOCYTE TRAFFICKING IN ATHEROSCLEROSIS AND AORTIC ANEURYSM FORMATION THROUGH ALTERED CHEMOKINE SIGNALLING

  Conference paper

  Patel J. et al, (2015), ATHEROSCLEROSIS, 241, E11 - E11

• Reducing In-Stent Restenosis: Therapeutic Manipulation of miRNA in Vascular Remodeling and Inflammation.

  Journal article

  McDonald RA. et al, (2015), J Am Coll Cardiol, 65, 2314 - 2327

• RGS1 regulates myeloid cell accumulation in atherosclerosis and aortic aneurysm rupture through altered chemokine signalling.

  Journal article

  Patel J. et al, (2015), Nat Commun, 6

• A requirement for Gch1 and tetrahydrobiopterin in embryonic development.

  Journal article

  Douglas G. et al, (2015), Dev Biol, 399, 129 - 138

• Cardiac dysfunction and peri-weaning mortality in malonyl-coenzyme A decarboxylase (MCD) knockout mice as a consequence of restricting substrate plasticity.

  Journal article

  Aksentijević D. et al, (2014), J Mol Cell Cardiol, 75, 76 - 87

• Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.

  Journal article

  Chuaiphichai S. et al, (2014), Hypertension, 64, 530 - 540

• P623RGS-1 modulates leukocyte trafficking in atherosclerosis and aortic aneurysm formation through chemokine receptor desensitisation.

  Conference paper

  Patel J. et al, (2014), Cardiovasc Res, 103 Suppl 1

• 303A cell-Autonomous role for endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.

  Conference paper

  Chuaiphichai S. et al, (2014), Cardiovasc Res, 103 Suppl 1

• Endothelial cell-specific reactive oxygen species production increases susceptibility to aortic dissection.

  Journal article

  Fan LM. et al, (2014), Circulation, 129, 2661 - 2672

• Tetrahydrobiopterin in cardiovascular health and disease.

  Journal article

  Bendall JK. et al, (2014), Antioxid Redox Signal, 20, 3040 - 3077

• YIA5 RGS-1 Regulates Leukocyte Trafficking in Atherosclerosis and Aortic Aneurysm Formation through Chemokine Receptor Desensitisation.

  Conference paper

  Patel J. et al, (2014), Heart, 100 Suppl 3

• A NEW ROLE FOR THE REGULATOR OF G-PROTEIN SIGNALLING-1 IN INFLAMMATORY CELL FUNCTION IN ANGIOTENSIN II-INDUCED AORTIC ANEURYSM FORMATION

  Conference paper

  Patel J. et al, (2014), ATHEROSCLEROSIS, 232, E7 - E7

• Metabolic Inflexibility of Malonyl CoA Decarboxylase (MCD) Knockout Mice Leads to Cardiac Remodelling and High Mortality During Peri-Weaning Period

  Conference paper

  Aksentijevic D. et al, (2014), BIOPHYSICAL JOURNAL, 106, 187A - 187A

• The pathogenesis of atherosclerosis

  Journal article

  Douglas G. and Channon KM., (2014), Medicine (United Kingdom), 42, 480 - 484

• Endothelial cell repopulation after stenting determines in-stent neointima formation: effects of bare-metal vs. drug-eluting stents and genetic endothelial cell modification.

  Journal article

  Douglas G. et al, (2013), Eur Heart J, 34, 3378 - 3388

• Tetrahydrobiopterin determines vascular remodeling through enhanced endothelial cell survival and regeneration.

  Journal article

  Ali ZA. et al, (2013), Circulation, 128, S50 - S58

• MicroRNA 21 is upregulated following coronary artery stenting and genetic deletion limits neointima formation

  Conference paper

  Halliday C. et al, (2013), EUROPEAN HEART JOURNAL, 34, 806 - 806

• Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2.

  Journal article

  Bishop T. et al, (2013), J Physiol, 591, 3565 - 3577

• Genetic ablation of microRNA-143 leads to reduced neointimal formation in mouse model of in-stent stenosis

  Conference paper

  Robinson HC. et al, (2013), HUMAN GENE THERAPY, 24, A35 - A35

• ENDOTHELIAL SPECIFIC NOX2 OVER-EXPRESSION INCREASES SUSCEPTIBILITY TO ANGIOTENSIN II INDUCED AORTIC DISSECTION

  Conference paper

  Fan L. et al, (2012), HEART, 98, A1 - A2

• Endothelial-specific Nox2 overexpression increases vascular superoxide and macrophage recruitment in ApoE⁻/⁻ mice.

  Journal article

  Douglas G. et al, (2012), Cardiovasc Res, 94, 20 - 29

• Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin.

  Journal article

  Adlam D. et al, (2012), Cardiovasc Res, 93, 694 - 701

• Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin

  Journal article

  Adlam D. et al, (2012), Cardiovascular Research, 93, 694 - 701

• Molecular imaging with optical coherence tomography using ligand-conjugated microparticles that detect activated endothelial cells: rational design through target quantification.

  Journal article

  Jefferson A. et al, (2011), Atherosclerosis, 219, 579 - 587

• Endothelial Specific Redox Signalling Regulates Susceptibility to Aortic Dissection Through Endothelial Cyclophilin A secretion

  Conference paper

  Fan L. et al, (2011), CIRCULATION, 124

• Increased Endothelial Tetrahydrobiopterin Reduces In Stent Stenosis in Apolipoprotein E-Knockout Mice

  Conference paper

  Ali ZA. et al, (2011), JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 58, B123 - B123

• Enhanced K(+)-channel-mediated endothelium-dependent local and conducted dilation of small mesenteric arteries from ApoE(-/-) mice.

  Journal article

  Beleznai T. et al, (2011), Cardiovasc Res, 92, 199 - 208

• Enhanced K +-channel-mediated endothelium-dependent local and conducted dilation of small mesenteric arteries from ApoE -/- mice

  Journal article

  Beleznai T. et al, (2011), Cardiovascular Research, 92, 199 - 208

• Targeted endothelial Nox2 over-expression potentiates angiotensin ii induced aortic dissection in mice

  Conference paper

  Fan LM. et al, (2010), ATHEROSCLEROSIS, 213, E16 - E16

• Endothelial-specific Nox2 over-expression increases vascular superoxide production but does not alter atherosclerotic plaque or AngII-dependent aneurysm formation

  Conference paper

  Douglas G. et al, (2010), ATHEROSCLEROSIS, 213, E12 - E13

• Tetrahydrobiopterin supplementation reduces atherosclerosis and vascular inflammation in apolipoprotein E-knockout mice.

  Journal article

  Schmidt TS. et al, (2010), Clin Sci (Lond), 119, 131 - 142

• Low-dose Tetrahydrobiopterin Supplementation Reduces Atherosclerosis Progression in Apolipoprotein E-Knockout Mice via Effects on Vascular T cell Infiltration

  Conference paper

  Schmidt TS. et al, (2009), CIRCULATION, 120, S1068 - S1068

• Arterial Stent Deployment Results in a Time Dependent Increase in Neointima Formation and Delayed Endothelial Cell Repopulation Compared With Balloon Angioplasty

  Conference paper

  Douglas G. et al, (2009), CIRCULATION, 120, S1171 - S1171

• Tetrahydrobiopterin (BH4) Improves Endothelial Cell Survival After Vascular Injury

  Conference paper

  Rinze R. et al, (2008), CIRCULATION, 118, S560 - S560

• CCR2-mediated antiinflammatory effects of endothelial tetrahydrobiopterin inhibit vascular injury-induced accelerated atherosclerosis.

  Conference paper

  Ali ZA. et al, (2008), Circulation, 118, S71 - S77

• Endothelial specific Nox2 overexpression increases vascular superoxide production but does not alter atherosclerotic plaque or neointima formation in mice

  Conference paper

  Douglas G. et al, (2008), ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 28, E43 - E43

• Functional characterization and sex differences in small mesenteric arteries of the estrogen receptor-beta knockout mouse.

  Journal article

  Douglas G. et al, (2008), Am J Physiol Regul Integr Comp Physiol, 294, R112 - R120

• Tetrahydrobiopterin-dependent eNOS coupling determines vascular remodeling through accelerated endothelial regeneration

  Conference paper

  Ali ZA. et al, (2007), JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 49, 421A - 421A

• Tetrahydrobiopterin-dependent eNOS coupling mediates endothelial regeneration and attenuates vein graft atherosclerosis in ApoE-KO mice

  Conference paper

  Ali ZA. et al, (2007), HEART, 93

• Cardiovascular consequences of life-long exposure to dietary isoflavones in the rat.

  Journal article

  Douglas G. et al, (2006), J Physiol, 571, 477 - 487

• Dilatory responses to estrogenic compounds in small femoral arteries of male and female estrogen receptor-beta knockout mice.

  Journal article

  Cruz MN. et al, (2006), Am J Physiol Heart Circ Physiol, 290, H823 - H829

Recent Publications

• A Genomic DNA Reporter Screen Identifies Squalene Synthase Inhibitors That Act Cooperatively with Statins to Upregulate the Low-Density Lipoprotein Receptor.

  Journal article

  Kerr AG. et al, (2017), J Pharmacol Exp Ther, 361, 417 - 428

• A key role for tetrahydrobiopterin-dependent endothelial NOS regulation in resistance arteries: studies in endothelial cell tetrahydrobiopterin-deficient mice.

  Journal article

  Chuaiphichai S. et al, (2017), Br J Pharmacol, 174, 657 - 671

• Episomal Nonviral Gene Therapy Vectors Slow Progression of Atherosclerosis in a Model of Familial Hypercholesterolemia.

  Journal article

  Kerr AG. et al, (2016), Mol Ther Nucleic Acids, 5

• Regulation of ventilatory sensitivity and carotid body proliferation in hypoxia by the PHD2/HIF-2 pathway.

  Journal article

  Hodson EJ. et al, (2016), J Physiol, 594, 1179 - 1195

• Episomal Nonviral Gene Therapy Vectors Slow Progression of Atherosclerosis in a Model of Familial Hypercholesterolemia.

  Journal article

  Kerr AG. et al, (2016), Mol Ther Nucleic Acids, 5