Contact information
Research groups
DPhil projects available
Assigning Functional Mechanisms to a New Coronary Artery Susceptibility Gene
Gillian Douglas
PhD
University Research Lecturer
Large studies linking common variations to the occurrence of coronary artery disease have enabled us to identify several new genes that may have a causative influence on the susceptibility to developing coronary artery disease. However, for many of these genes the mechanism by which they alter cardiovascular disease pathology is unknown.
Recent publications
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Mammalian γ2 AMPK regulates intrinsic heart rate.
Journal article
Yavari A. et al, (2017), Nat Commun, 8
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A Genomic DNA Reporter Screen Identifies Squalene Synthase Inhibitors That Act Cooperatively with Statins to Upregulate the Low-Density Lipoprotein Receptor.
Journal article
Kerr AG. et al, (2017), J Pharmacol Exp Ther, 361, 417 - 428
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A key role for tetrahydrobiopterin-dependent endothelial NOS regulation in resistance arteries: studies in endothelial cell tetrahydrobiopterin-deficient mice.
Journal article
Chuaiphichai S. et al, (2017), Br J Pharmacol, 174, 657 - 671
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Episomal Nonviral Gene Therapy Vectors Slow Progression of Atherosclerosis in a Model of Familial Hypercholesterolemia.
Journal article
Kerr AG. et al, (2016), Mol Ther Nucleic Acids, 5
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WORKSHOP 3.1: NOVEL THERAPIES. A NOVEL COMBINATORIAL NON-VIRAL VECTOR TO TREAT FAMILIAL HYPERCHOLESTEROLAEMIA (FH)
Conference paper
Kerr A. et al, (2016), ATHEROSCLEROSIS, 252, E238 - E238