Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Invariant natural killer T (iNKT) cells recognize endogenous and exogenous lipids in the context of CD1d molecules, and through the activation and maturation of dendritic cells and B cells, can significantly enhance priming of antigen-specific T and B cell responses. Recent findings have provided important insights into the recognition of several novel endogenous lipids by iNKT cells, and into the mechanisms controlling their generation and loading onto CD1d molecules. In this review we discuss these latest findings and describe the role of autophagy in iNKT cell development and activation.

Original publication

DOI

10.1016/j.coi.2015.03.004

Type

Journal article

Journal

Curr Opin Immunol

Publication Date

06/2015

Volume

34

Pages

116 - 125

Keywords

Animals, Antigen Presentation, Antigens, CD1d, Autophagy, B-Lymphocytes, Dendritic Cells, Gastrointestinal Microbiome, Humans, Lipids, Natural Killer T-Cells