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Rfam is a collection of RNA sequence families, represented by multiple sequence alignments and covariance models (CMs). The primary aim of Rfam is to annotate new members of known RNA families on nucleotide sequences, particularly complete genomes, using sensitive BLAST filters in combination with CMs. A minority of families with a very broad taxonomic range (e.g. tRNA and rRNA) provide the majority of the sequence annotations, whilst the majority of Rfam families (e.g. snoRNAs and miRNAs) have a limited taxonomic range and provide a limited number of annotations. Recent improvements to the website, methodologies and data used by Rfam are discussed. Rfam is freely available on the Web at http://rfam.sanger.ac.uk/and http://rfam.janelia.org/.

Original publication

DOI

10.1093/nar/gkn766

Type

Journal article

Journal

Nucleic Acids Res

Publication Date

01/2009

Volume

37

Pages

D136 - D140

Keywords

Computer Graphics, Databases, Nucleic Acid, Internet, RNA, Sequence Alignment, Sequence Analysis, RNA