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Regional chemotherapy is commonly used to treat patients with colorectal liver metastases. However, improvement in survival has still not been demonstrated. Cytotoxic loaded albumin microspheres for arterial administration have been described as a means of improving the the therapeutic index, but their distribution depends upon the prevailing pattern of arterial blood-flow at the time of injection. In this study, the ability of the vasoactive drug angiotensin II to target arterially injected microspheres to colorectal liver metastases is assessed in nine patients using scintigraphic planar and tomographic imaging. The median tumour: normal ratio in nine patients with colorectal liver metastases was 3.4:1 before the administration of angiotensin II. The corresponding ratio after administration of angiotensin II was 7.3:1. The median improvement factor was 1.8 (P less than 0.05). The data suggest that worthwhile tumour targeting can be achieved with angiotensin II in patients with colorectal liver metastases.

Original publication

DOI

10.1038/bjc.1991.252

Type

Journal article

Journal

Br J Cancer

Publication Date

07/1991

Volume

64

Pages

114 - 119

Keywords

Angiotensin II, Colonic Neoplasms, Drug Carriers, Humans, Liver Neoplasms, Microspheres, Rectal Neoplasms, Technetium Tc 99m Aggregated Albumin, Tomography, Emission-Computed