Publications — Radcliffe Department of Medicine

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NG2 is a target gene of MLL-AF4 and underlies glucocorticoid resistance in MLL-r B-ALL by regulating NR3C1 expression.

Lopez-Millan B. et al, (2024), Blood

Chromatin and aberrant enhancer activity in KMT2A rearranged acute lymphoblastic leukemia.

Milne TA., (2024), Curr Opin Genet Dev, 86

Iron deficiency causes aspartate-sensitive metabolic and proliferative dysfunction in CD8+ T cells

Teh MR. et al, (2024)

HDAC inhibitor derivatives induce differentiation of leukemic cells through two distinct and separable mechanisms

Kumar P. et al, (2024)

Effects of glycation end-products on the dental pulp in patients with type 2 diabetes.

Alsamahi S. et al, (2023), Int Endod J, 56, 1373 - 1384

Mutate and Conjugate: A Method to Enable Rapid In-Cell Target Validation.

Thomas AM. et al, (2023), ACS Chem Biol

A human genome editing-based MLL::AF4 B-cell ALL model recapitulates key cellular and molecular leukemogenic features.

Bueno C. et al, (2023), Blood

Modelling acquired resistance to DOT1L inhibition exhibits the adaptive potential of KMT2A-rearranged acute lymphoblastic leukemia.

Schneider P. et al, (2023), Exp Hematol Oncol, 12

MLL-AF4 cooperates with PAF1 and FACT to drive high-density enhancer interactions in leukemia.

Crump NT. et al, (2023), Nat Commun, 14

Author Correction: Capture-C: a modular and flexible approach for high-resolution chromosome conformation capture.

Downes DJ. et al, (2023), Nat Protoc

Phenotypic screening identifies a trisubstituted imidazo[1,2-a]pyridine series that induces differentiation in multiple AML cell lines.

Josa-Culleré L. et al, (2023), Eur J Med Chem, 258

Active regulatory elements recruit cohesin to establish cell-specific chromatin domains

Georgiades E. et al, (2023)

Disrupted propionate metabolism evokes transcriptional changes in the heart by increasing histone acetylation and propionylation

Park KC. et al, (2023), Nature Cardiovascular Research

Dysregulation of chromatin via H3K27 methylation underpins differentiation arrest in Isocitrate dehydrogenase-mutant Acute Myeloid Leukaemia

Silveira DRA. et al, (2023)

PROM1/CD133 expression identifies highly proliferative MLL-AF4+blasts and correlates with a stem-like gene signature

Cross J. et al, (2023), KLINISCHE PADIATRIE, 235, 193 - 193

A tubulin binding molecule drives differentiation of acute myeloid leukemia cells.

Jackson TR. et al, (2022), iScience, 25

PAF1 and FACT cooperate with MLL-AF4 to drive enhancer activity in leukemia

Crump NT. et al, (2022)

Alkaline nucleoplasm facilitates contractile gene expression in the mammalian heart.

Hulikova A. et al, (2022), Basic Res Cardiol, 117

Potent, p53-independent induction of NOXA sensitizes MLL-rearranged B-cell acute lymphoblastic leukemia cells to venetoclax.

Fidyt K. et al, (2022), Oncogene, 41, 1600 - 1609

Capture-C: a modular and flexible approach for high-resolution chromosome conformation capture.

Downes DJ. et al, (2022), Nat Protoc

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