Publications — Radcliffe Department of Medicine

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Loss of electrical β-cell to δ-cell coupling underlies impaired hypoglycaemia-induced glucagon secretion in type-1 diabetes.

Hill TG. et al, (2024), Nat Metab

Author Correction: Every islet matters: improving the impact of human islet research

Gloyn AL. et al, (2024), Nature Metabolism

Electrophysiological characterisation of iPSC-derived human β-like cells and an SLC30A8 disease model.

Jaffredo M. et al, (2024), Diabetes

The endoplasmic reticulum plays a key role in α-cell intracellular Ca2+ dynamics and glucose-regulated glucagon secretion in mouse islets.

Acreman S. et al, (2024), iScience, 27

An unclear role for the GLP-1 metabolite GLP-1(9–36) in human islet physiology. Reply to Matveyenko A, Vella A [letter]

Gandasi NR. and Rorsman P., (2024), Diabetologia

GLP-1 metabolite GLP-1(9-36) is a systemic inhibitor of mouse and human pancreatic islet glucagon secretion.

Gandasi NR. et al, (2023), Diabetologia

Glucose Controls Glucagon Secretion by Regulating Fatty Acid Oxidation in Pancreatic α-Cells.

Armour SL. et al, (2023), Diabetes, 72, 1446 - 1459

Platelet-derived lipids promote insulin secretion of pancreatic β cells.

Karwen T. et al, (2023), EMBO Mol Med

History of key regulatory peptide systems and perspectives for future research

Chen D. et al, (2023), Journal of Neuroendocrinology

Metabolic Messengers: glucagon.

MacDonald PE. and Rorsman P., (2023), Nat Metab

Electrophysiological characterisation of iPSC-derived human β-like cells and anSLC30A8disease model.

Jaffredo M. et al, (2023)

Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells.

Haythorne E. et al, (2022), Nat Commun, 13

Hindbrain insulin controls feeding behavior.

Eerola K. et al, (2022), Mol Metab

Every islet matters: improving the impact of human islet research

Gloyn AL. et al, (2022), Nature Metabolism

Reducing hyperglucagonaemia in type 2 diabetes using low-dose glibenclamide: Results of the LEGEND-A pilot study.

Spiliotis II. et al, (2022), Diabetes Obes Metab, 24, 1671 - 1675

A critical role of the mechanosensor PIEZO1 in glucose-induced insulin secretion in pancreatic β-cells.

Ye Y. et al, (2022), Nat Commun, 13

Adipocyte-specific ablation of the Ca2+ pump SERCA2 impairs whole-body metabolic function and reveals the diverse metabolic flexibility of white and brown adipose tissue.

Bauzá-Thorbrügge M. et al, (2022), Mol Metab

Acetyl-CoA-carboxylase 1 (ACC1) plays a critical role in glucagon secretion.

Veprik A. et al, (2022), Commun Biol, 5

Adipocyte-specific ablation of the Ca2+ pump SERCA2 impairs whole-body metabolic function and reveals the diverse metabolic flexibility of white and brown adipose tissue

Bauzá-Thorbrügge M. et al, (2022)

Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state.

Dai X-Q. et al, (2022), Cell Metab, 34, 256 - 268.e5

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