Emily Georgiades

I have recently completed my DPhil through the Wellcome Trust Genomic Medicine and Statistics DPhil programme. 

My PhD project was titled “Dynamics in the Regulatory Genome”, in which I was investigating the role of cohesin in regulating 3D genome architecture. I combined genome engineering, live-cell imaging, genomics and computational analysis to develop a novel method to capture the dynamic process of cohesin recruitment and migration.

During the first year of my DPhil I completed rotation projects in both Professor Doug Higgs’ and Jim Hughes’ labs.  For my first project in the Higgs lab, I implemented a tiled approach to the capture-C method to investigate chromosome conformation and the subsequent regulation of gene expression across selected regions of interest.  For the second rotation in the Hughes group, I moved out of the lab to a purely computational project where I used machine learning methodologies with the aim of developing a model capable of identifying promoter CpG islands.

In 2017 I graduated from the University of Bath with a first-class MSci in Natural Sciences, majoring in Chemistry with Biology, with an industrial placement year in the Human Genetics department at Pfizer.  For the year prior to starting my DPhil I worked as research technician in Professor Anna Gloyn’s lab at the Oxford Centre for Diabetes and Endocrinology on functional genomics projects within the remit of type 2 diabetes.