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Using a range of imaging modalities, our researchers can probe – at the molecular level – the events that underpin cellular health and dysfunction.

Dying cell

The Wolfson Imaging Centre is a flagship facility for cellular and pre-clinical imaging, including confocal microscopy coupled with live-cell analysis.



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The WOLFSON iMAGING CENTRE

The Wolfson Imaging Centre contains a diverse range of wide-field and confocal microscopes suitable for imaging specimens ranging in complexity from single cells to small laboratory animals.

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Cellular and Preclinical Imaging DPhil Projects

Actin cytoskeleton-mediated force generation during T-cell activation investigated by advanced (super-resolution) microscopy

Advanced Image Analysis of Cardiovascular Magnetic Resonance T1-maps 

Analysis of blood stem cell lineage specification in mammalian development

Analysis of De Novo Mutations in the Human Testis

Analysis of lipid and lipid-anchored protein organization at the T-cell surface using novel super-resolution (STED-FCS) microscopy

Analysis of lipid-antigen assisted T-cell activation using live-cell super-resolution (STED) microscopy

Application of pharmacological, gene silencing and cell biological techniques to explore the effects of the gut hormone GLP-1 on glucagon release

Assigning Functional Mechanisms to a New Coronary Artery Susceptibility Gene

Biophysical mechanisms of Cardiovascular T1 mapping

Cardiac energetics as a translational target for heart disease

Chromatin remodeling and gene expression

Engineered induced pluripotent stem cell lines for phenotypic selection of cardiac cell types

Exploring the role of Z-disk structure and signalling for striated muscle integrity with the help of genome-edited mouse models of cardiomyopathy

Exploring the relationship between DPP-IV inhibition and PYY mediated control of hyperglycaemia in health and diabetes by means of biochemical, cell biological and metabolomic techniques

Functional analyses of newly implicated genes for inherited heart muscle diseases

Functional genomic analysis of genetic susceptibility loci for coronary artery disease

Go with the Flow: An integrative approach to study cardiovascular disease

Identification of the atrial transcriptional signature of patients who develop atrial fibrillation

Impact of De Novo Mutations and Mosaicism in Human Disease: Applications to Non-Invasive Diagnostic Techniques

Investigating the role of calcitonin in electrophysiological function in cardiomyocytes

Investigating the role of non-coding RNAs in fibrogenesis

Microscopy-based analysis of lipid and lipid-anchored protein organization at the T-cell surface

Role of homoarginine in cardiac health and disease

A role of long non-coding RNA loc554202 in atrial fibrosis

Screening for novel mechanosensors in cardiovascular disease

Whole genome sequencing to identify new disease genes for hypertrophic cardiomyopathy

All DPhil projects