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A raft of cellular and molecular biology techniques underpin much of the work we do to elucidate the mechanisms of disease. We use established techniques to answer new questions and also develop our own novel and unique methodologies to drive further innovation.

Scar in a jar Angela Lee
Primary human dermal fibroblasts were treated with a macromolecular crowder that condenses extracellular matrix for a more accurate physiological representation.

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Our Divisions

Our divisions cluster experts in particular disease areas and experimental techniques.

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Cellular and Molecular Biology DPhil Projects

AMMF Funded Project: An integrated analysis of proteomics and metabolomics in cholangiocarcinoma to identify pathways for target development programme

Actin cytoskeleton-mediated force generation during T-cell activation investigated by advanced (super-resolution) microscopy

Advanced Image Analysis of Cardiovascular Magnetic Resonance T1-maps 

AKR1C1 as a therapeutic target in non-alcholoic fatty liver diease and hepatocellular carcinoma

Analysis of blood stem cell lineage specification in mammalian development

Analysis of De Novo Mutations in the Human Testis

Analysis of lipid and lipid-anchored protein organization at the T-cell surface using novel super-resolution (STED-FCS) microscopy

Analysis of lipid-antigen assisted T-cell activation using live-cell super-resolution (STED) microscopy

Application of pharmacological, gene silencing and cell biological techniques to explore the effects of the gut hormone GLP-1 on glucagon release

Assigning Functional Mechanisms to a New Coronary Artery Susceptibility Gene

Biophysical mechanisms of Cardiovascular T1 mapping

Brown adipose tissue WNT signalling as a therapeutic target for obesity and type 2 diabetes

Cardiac energetics as a translational target for heart disease

Characterisation of molecular pathways of differentiation in normal human lympho-myeloid differentiation using a systems biology approach

Characterisation of Viral OncoProtein (VOP) and Tumor specific Protein (TSP) specific T cell responses in HPV virus associated Cervical and head-neck Cancers

Chromatin remodeling and gene expression

Combining genome-editing in human IPS cells with Type 2 diabetes genomics to decipher mechanisms for islet dysfunction

Controlling malaria through manipulating iron transport

Defining human hepatic insulin resistance

Developing a framework for precision medicine in a complex trait

Development of Gene Therapy & Gene Editing for Lung Disorders

Engineered induced pluripotent stem cell lines for phenotypic selection of cardiac cell types

Epigenetic programming of hematopoietic stem cells and their progeny

Exome and whole genome sequencing to identify new genetic causes of skull malformations

Exploring the role of Z-disk structure and signalling for striated muscle integrity with the help of genome-edited mouse models of cardiomyopathy

Exploring the relationship between DPP-IV inhibition and PYY mediated control of hyperglycaemia in health and diabetes by means of biochemical, cell biological and metabolomic techniques

Functional analyses of newly implicated genes for inherited heart muscle diseases

Functional genomic analysis of genetic susceptibility loci for coronary artery disease

Go with the Flow: An integrative approach to study cardiovascular disease

How do cranial sutures work?

Human Model of DS-AML: Identifying mechanisms of differentiation arrest leading to Acute Myeloid Leukaemia

Identification of the atrial transcriptional signature of patients who develop atrial fibrillation

Identifying new molecular players determining metabolic disease risk and susceptibility to osteoporosis 

Identifying novel genetic causes of pituitary cancers

Identifying novel therapeutic strategies for endocrine cancers

Impact of De Novo Mutations and Mosaicism in Human Disease: Applications to Non-Invasive Diagnostic Techniques

The impact of IFITM3 genetic variation on virus infection, immune responses and disease outcome

The influence of dietary fatty acids on regional adipose tissue development and function

Investigating the role of calcitonin in electrophysiological function in cardiomyocytes

Investigating the role of non-coding RNAs in fibrogenesis

In vivo modelling of mutation order and oncogene addiction in myeloproliferative neoplasms

Iron deficiency and immunity

Microscopy-based analysis of lipid and lipid-anchored protein organization at the T-cell surface

Molecular mechanism of familial partial lipodystrophy

Niche determinants required for leukaemic and normal stem cell function

Role of CD1a-restricted T cells in human inflammation and translational development of new therapies to treat allergic disease

The role of hematopoeitic stem cell heterogeneity in hematopoietic emergency responses

Role of homoarginine in cardiac health and disease

Role of Innate Lymphoid Cells in skin inflammation

A role of long non-coding RNA loc554202 in atrial fibrosis

The role of the transcription factor Nuclear Factor I/X (NFIX) in the pathogenesis of Marshall-Smith Syndrome (MSS)

Screening for novel mechanosensors in cardiovascular disease

Single cell analysis of malignant stem cell clones in myelofibrosis

Studying blood stem cell development through single cell and lineage tracing analyses

Whole genome sequencing to identify new disease genes for hypertrophic cardiomyopathy

All DPhil projects