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BACKGROUND AND AIMS: Imaging studies have relied on the 'overall' volumetric quantification of perivascular adipose tissue. We sought to assess the relationship of circumferential distribution between perivascular adipose tissue and adjacent wall thickness of carotid and aortic arteries using dedicated magnetic resonance imaging sequences. METHODS: Vessel wall and perivascular adipose tissue were acquired using magnetic resonance imaging (1.5 T). Co-registered images were segmented separately, and measurements of both perivascular adipose tissue and vessel wall were obtained along radii of the vessel spaced at angles of 5° each. RESULTS: In total, 29 patients were recruited. Perivascular adipose tissue thickness of the aorta was 3.34 ± 0.79 mm with specific pattern of 'double peaks' distribution, while carotid perivascular adipose tissue had no identifiable pattern with thickness of 0.8 ± 0.91 mm. Although statistically significant, the correlation between perivascular adipose tissue thickness and wall thickness in carotid arteries with normal (r = 0.040, p = 0.001) or with abnormal wall thickness (r = -0.039, p = 0.015) was merely nominal. Similarly, perivascular adipose tissue of the aorta had very weak correlation with normal aortic wall thickness (r = 0.010, p = 0.008) but not with the abnormal ones (r = -0.05, p = 0.29). CONCLUSION: Dissociation between the spatial distribution of perivascular adipose tissue and arterial wall thickening in the aorta and carotid arteries does not support that perivascular adipose tissue has a causal role in promoting atherosclerotic plaque via a paracrine route. Yet, perivascular adipose tissue functional properties were not examined in this study.

Original publication

DOI

10.1177/1479164118757923

Type

Journal article

Journal

Diab Vasc Dis Res

Publication Date

07/2018

Volume

15

Pages

286 - 293

Keywords

Perivascular adipose tissue, aorta, atherosclerosis, carotid arteries, magnetic resonance imaging, Adipose Tissue, Aged, Aorta, Thoracic, Aortic Diseases, Atherosclerosis, Carotid Arteries, Carotid Artery Diseases, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Plaque, Atherosclerotic, Predictive Value of Tests