Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

New spectroscopic and imaging methods have been developed for quantitatively measuring magnetization transfer (MT). These methods use trains of radiofrequency (rf) pulses with pulse separations much longer than 1/k(mf) and pulse durations much shorter than 1/k(mf), where k(mf) is the rate of MT from the immobile (macromolecular) protons to the mobile (free water) protons. Signal sensitivity to MT occurs when these pulses affect the mobile and immobile proton pools to different degrees. The signal from water may be quantitatively related to the macromolecular content of the sample using theory. The method has been used to make quantitative measurements of macromolecular content in cross-linked bovine serum albumin and employed in conjunction with echoplanar imaging to produce maps of the spatial distribution of the macromolecular content.

Type

Journal article

Journal

Magn Reson Med

Publication Date

05/1999

Volume

41

Pages

1065 - 1072

Keywords

Algorithms, Animals, Artifacts, Cattle, Cross-Linking Reagents, Echo-Planar Imaging, Feasibility Studies, Image Processing, Computer-Assisted, Macromolecular Substances, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Models, Chemical, Protons, Radio Waves, Serum Albumin, Bovine, Time Factors, Water