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BACKGROUND: Noncontact charge-density mapping allows rapid real-time global mapping of atrial fibrillation (AF), offering the opportunity for a personalized ablation strategy. OBJECTIVE: The purpose of this study was to compare the 2-year outcome of an individualized strategy consisting of pulmonary vein isolation (PVI) plus core-to-boundary ablation (targeting the conduction pattern core with an extension to the nearest nonconducting boundary) guided by charge-density mapping, with an empirical PVI plus posterior wall electrical isolation (PWI) strategy. METHODS: Forty patients (age 62 ± 12 years; 29 male) with persistent AF (10 ± 5 months) prospectively underwent charge-density mapping-guided PVI, followed by core-to-boundary stepwise ablation until termination of AF or depletion of identified cores. Freedom from AF/atrial tachycardia (AT) at 24 months was compared with a propensity score-matched control group of 80 patients with empirical PVI + PWI guided by conventional contact mapping. RESULTS: Acute AF termination occurred in 8 of 40 patients after charge-density mapping-guided PVI alone and in 21 of the remaining 32 patients after core-to-boundary ablation in the study cohort, compared with 8 of 80 (10%) in the control cohort (P 

Original publication




Journal article


Heart Rhythm

Publication Date





862 - 870


Catheter ablation, Conduction pattern core, Driver, Maintainer, Noncontact charge-density mapping, Persistent atrial fibrillation, Atrial Fibrillation, Body Surface Potential Mapping, Catheter Ablation, Female, Follow-Up Studies, Heart Conduction System, Heart Rate, Humans, Male, Middle Aged, Propensity Score, Prospective Studies, Pulmonary Veins, Recurrence, Surgery, Computer-Assisted, Time Factors, Treatment Outcome