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Siyu Chen
DPhil Student
My DPhil research focuses on the circadian regulation of macrophage immune response and metabolism in health and chronic inflammatory diseases. Using a combination of experimental and computational approaches, I’m working to understand how macrophages align their daily activities with the optimal time and tissue environment.
Prior to this, I completed my BSc degree in Biological Sciences at Sun Yat-sen University in China with an Outstanding Graduates award, and my MSc degree in Integrated Immunology at the University of Oxford.
Beyond my DPhil studies, I’m passionate about science communication. By infusing science with the art of illustration and the craft of writing, I’m hoping to make it more accessible and meaningful in people’s lives.
Publications
The clockwork macrophage: timing in innate immunity. Chen, S., Ciccone, N. & Ray, D. Biomedical Journal, 100872, doi:https://doi.org/10.1016/j.bj.2025.100872 (2025).
Comprehensive detrimental effects of a simulated frequently shifting schedule on diurnal rhythms and vigilance. Ma, X. et al. Chronobiology International 39, 1-12, doi:10.1080/07420528.2022.2101371 (2022).
Circadian misalignment leads to changes in cortisol rhythms, blood biochemical variables and serum miRNA profiles. Huang, G. et al. Biochemical and biophysical research communications 567, 9-16, doi:10.1016/j.bbrc.2021.06.015 (2021).