Research groups
Colleges
David Ray
FRCP PhD
Professor of Endocrinology, Head of OCDEM, and Co-Director Sir Jules Thorn Sleep and Circadian Neuroscience Institute
- Professor of Endocrinology, University of Oxford
- Head, Oxford Centre for Diabetes, Endocrinology and Metabolism
- Co-Director of the Sir Jules Thorn Sleep and Circadian Neuroscience Institute, University of Oxford
- Executive member Oxford Metabolic Health
- Investigator Kavli Institute for Nanoscience Discovery, University of Oxford
Circadian and sleep regulation of inflammation, and metabolism, and the role of nuclear receptors in health and disease.
David trained in general internal medicine in North West England, and obtained a PhD from the University of Manchester. He was a research fellow at UCLA for two years, working on neuroendocrine-immune interaction, before returning to the UK, and obtaining a GSK fellowship to work on glucocorticoid action, and sensitivity in inflammatory disease. He was promoted to Professor of Medicine at the University of Manchester in 2005, and went on to study nuclear receptor and circadian biology in inflammation, and energy metabolism. This work attracted Wellcome Investigator and MRC programme grant support.
David is a passionate advocate of research training, serving on the MRC clinical fellowship panel for seven years, three as deputy chair.
Circadian mechanisms regulate most mammalian physiology, with particular importance in the regulation of innate immunity, through the macrophage in particular, and energy metabolism, regulating liver, adipose and muscle. These circuits are also regulated by a number of nuclear receptors, which show a striking interdependency on the circadian machinery; some having ligand availability regulated by the clock, others varying in expression level through the day. We have employed a range of approaches to address the physiological importance of the circadian:nuclear receptor system, ranging from population genetics, experimental medicine studies, CRISPR engineered mice, and cell biology. These approaches have discovered how the important dimension of time regulates metabolism, and coordinates diverse tissues to deliver optimal organismal performance. Importantly, we are identifying how external stressors can decouple these systems, with deleterious effects.
Key publications
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Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation.
Journal article
Pariollaud M. et al, (2018), J Clin Invest, 128, 2281 - 2296
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Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits.
Journal article
Lane JM. et al, (2017), Nat Genet, 49, 274 - 281
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Glucocorticoid receptor regulates accurate chromosome segregation and is associated with malignancy.
Journal article
Matthews LC. et al, (2015), Proc Natl Acad Sci U S A, 112, 5479 - 5484
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An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action.
Journal article
Gibbs J. et al, (2014), Nat Med, 20, 919 - 926
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The nuclear receptor REV-ERBα mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines.
Journal article
Gibbs JE. et al, (2012), Proc Natl Acad Sci U S A, 109, 582 - 587
Recent publications
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Author Correction: Self-supervised learning of accelerometer data provides new insights for sleep and its association with mortality.
Journal article
Yuan H. et al, (2024), NPJ Digit Med, 7
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LDHB contributes to the regulation of lactate levels and basal insulin secretion in human pancreatic β cells
Journal article
Hodson D., (2024), Cell Reports
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Evaluating the Cardiovascular Impact of Genetically Proxied PCSK9 and HMGCR Inhibition in East Asian and European Populations: A Drug-Target Mendelian Randomization Study.
Journal article
Rosoff DB. et al, (2024), Circ Genom Precis Med
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Self-supervised learning of accelerometer data provides new insights for sleep and its association with mortality
Journal article
Yuan H. et al, (2024), npj Digital Medicine
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Chronotype, but Not Night-Shift Work, Is Associated with Psoriasis: a Cross-Sectional Study Among UK Biobank Participants.
Journal article
Maidstone R. et al, (2023), J Invest Dermatol