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BACKGROUND: A defect in hypothalamic-pituitary-adrenal (HPA) axis function has been suggested to contribute to susceptibility to rheumatoid arthritis (RA). OBJECTIVE: To investigate polymorphisms of the glucocorticoid receptor (GR) gene and determine any associations with RA. METHODS: Three GR polymorphisms that tag 95% of all haplotypes across the GR gene were genotyped. These are an intron B Bcl1 polymorphism, a ttg insertion/deletion within intron F (rs2307674) and the single nucleotide polymorphism (SNP) lying in the 3' untranslated region of exon 9b (rs6198). The dye terminator-based SNaPshot method or size resolution by capillary electrophoresis was performed. The study population comprised 198 UK Caucasian RA cases and 393 ethnically matched controls. RESULTS: No significant single point or haplotypic associations were found for GR polymorphisms with RA susceptibility. Furthermore, no evidence for GR polymorphisms with aspects of RA severity was seen. CONCLUSION: In this study of the most comprehensive coverage of GR polymorphisms with RA, no significant contributing role for GR polymorphisms with RA was found.

Original publication

DOI

10.1111/j.1365-2265.2007.02887.x

Type

Journal article

Journal

Clin Endocrinol (Oxf)

Publication Date

09/2007

Volume

67

Pages

342 - 345

Keywords

Adult, Age of Onset, Arthritis, Rheumatoid, European Continental Ancestry Group, Genetic Predisposition to Disease, Haplotypes, Humans, Introns, Polymorphism, Single Nucleotide, Receptors, Glucocorticoid, United Kingdom