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© Springer International Publishing Switzerland 2015. The genetic cardiomyopathies are a group of inherited heart disorders with variable pathophysiology and clinical phenotype. As an example, hypertrophic cardiomyopathy will be discussed in this chapter. Clinical features and therapeutic options will be outlined, followed by a review of the underlying genetics of disease. The pathomechanisms of causative mutations will be discussed, with reference to both sarcomeric and non-sarcomeric genes. Finally, the potential and pitfalls of next-generation sequencing as applied to genetic cardiomyopathies will be analysed.

Original publication

DOI

10.1007/978-3-319-15263-9_11

Type

Chapter

Book title

Cardiac Cytoarchitecture: How to Maintain a Working Heart

Publication Date

01/01/2015

Pages

227 - 243