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The effects of a non-ionic polyoxyethylated lauryl ether surfactant (Brij 30) on monolayer uptake and spheroid penetration of adriamycin have been studied. Co-incubation of adriamycin with Brij 30 increases intracellular adriamycin levels by 2-3-fold. Although, in the concentrations used, Brij 30 alone is not cytotoxic, adriamycin and Brij 30 mixtures are significantly more cytotoxic (monolayer ID90 = 0.6 microgram/ml; disaggregated spheroid ID50 = 1.9 micrograms/ml) and induce significantly longer spheroid growth delay than adriamycin alone (monolayer ID90 = 2.1 micrograms/ml; disaggregated spheroid ID50 = 3.3 micrograms/ml). Adriamycin is equally cytotoxic to mouse normal granulocytes and chronic myeloid leukaemic (M1 cell line) cells in agar clonogenic cultures. The addition of Brij 30 appears to enhance preferentially the activity of adriamycin against these tumour cells relative to the normal granulocytes.

Original publication

DOI

10.1016/0277-5379(87)90114-3

Type

Journal article

Journal

Eur J Cancer Clin Oncol

Publication Date

09/1987

Volume

23

Pages

1315 - 1322

Keywords

Animals, Cell Line, Cell Survival, Clone Cells, Detergents, Dose-Response Relationship, Drug, Doxorubicin, Drug Synergism, Granulocytes, Humans, Mice, Polidocanol, Polyethylene Glycols, Surface-Active Agents, Time Factors