Shoumo Bhattacharya
Professor of Cardiovascular Medicine
- Honorary Consultant Cardiologist
Shoumo Bhattacharya is Professor of Cardiovascular Medicine in the RDM Division of Cardiovascular Medicine at the University of Oxford and is based at the Centre for Human Genetics. He read Medicine at the All-India Institute of Medical Sciences New Delhi, qualifying MBBS 1983, and MD 1985. He worked on the immunology of rheumatic fever with Anand Malviya and Rajan Tandon for his MD Thesis. Following clinical training in Cardiology with Edward Raftery at Northwick Park Hospital, Harrow, he worked with Avijit Lahiri on myocardial imaging agents and phase-I trials of abciximab. He joined James Scott’s group at the Clinical Research Centre, Harrow as an MRC Training Fellow in 1990, and worked on the mechanism of RNA editing. In parallel, he also read Biochemistry at King's College London, obtaining a Masters degree with Distinction in 1992. With fellowships from the BHF and then the NIH, he joined David Livingston’s group at Dana-Farber Cancer Institute/ Harvard Medical School in 1994, where he worked on how viral oncoproteins target the host. Here he discovered the role of EP300/CREBBP in interferon signalling, and of CITED2 in hypoxia signalling. He continued the work on CITED2 at Oxford from 1998-2008 as a Wellcome Senior Fellow, establishing the role of this gene in left-right patterning and heart development. Here, together with Jurgen Schneider he developed high-throughput magnetic resonance microscopy for studies of cardiac development. Using this he deciphered the role of multiple genes in heart development, and the role of PCSK5 in antero-posterior patterning. He established the BHF Genetic Origins of Congenital Heart Disease Study and as a member of the UK10K Consortium contributed to the understanding of the genetics of human cardiac malformation. He was elected Fellow of the Royal College of Physicians in 2003, awarded the Graham Bull Prize of the Royal College of Physicians in 2005, elected Fellow of the Academy of Medical Sciences in 2006, awarded a BHF Chair in 2009, and elected to a Statutory Professorship of Cardiovascular Medicine at the University of Oxford in 2010. The focus of his lab since 2015 has been the development of therapeutics from naturally occurring evasin proteins from ticks that target the host chemokine network in inflammation.
Key publications
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Journal article
Vales S. et al, (2023), Nat Commun, 14
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Bhusal RP. et al, (2020), Trends Biochem Sci, 45, 108 - 122
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Lee AW. et al, (2019), J Biol Chem, 294, 11199 - 11212
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Eaton JRO. et al, (2018), J Biol Chem, 293, 6134 - 6146
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Alenazi Y. et al, (2018), Sci Rep, 8
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Singh K. et al, (2017), Sci Rep, 7
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Szumska D. et al, (2008), Genes Dev, 22, 1465 - 1477
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Bamforth SD. et al, (2001), Nat Genet, 29, 469 - 474
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Bamforth SD. et al, (2004), Nat Genet, 36, 1189 - 1196
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Bhattacharya S. et al, (1999), Genes Dev, 13, 64 - 75
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Bhattacharya S. et al, (1996), Nature, 383, 344 - 347
Recent publications
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Bhattacharya SHOUMO., (2025), Communications Biology
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Kelm N. et al, (2025), Basic Res Cardiol
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Davies B. et al, (2024), Transgenic Res
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Vales S. et al, (2023), Nat Commun, 14
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Conference paper
Moreira L. et al, (2022), JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 173, S85 - S86
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Journal article
Singh K. et al, (2021), Sci Rep, 11
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Bhattacharya S. and Nuttall PA., (2021), Front Cell Infect Microbiol, 11
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Singh K. et al, (2021), Front Immunol, 12
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Calcitonin paracrine signaling controls atrial fibrogenesis and arrhythmia
Journal article
MOREIRA LM. et al, (2020), Nature
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Darlot B. et al, (2020), J Biol Chem, 295, 10926 - 10939