Publications — Radcliffe Department of Medicine

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Evasins: Tick Salivary Proteins that Inhibit Mammalian Chemokines

Bhusal RP. et al, (2019), Trends in Biochemical Sciences

A knottin scaffold directs the CXC-chemokine-binding specificity of tick evasins.

Lee AW. et al, (2019), J Biol Chem

Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate.

Gao R. et al, (2019), Cell Res, 29, 486 - 501

Bi-allelic Loss-of-Function CACNA1B Mutations in Progressive Epilepsy-Dyskinesia.

Gorman KM. et al, (2019), Am J Hum Genet, 104, 948 - 956

IDENTIFICATION OF THE MAJOR GENETIC CONTRIBUTORS TO TETRALOGY OF FALLOT

Page DJ. et al, (2019), HEART, 105, A182 - A183

Biowire Model of Interstitial and Focal Cardiac Fibrosis

Wang EY. et al, (2019), ACS Central Science

Tetrahydrobiopterin modulates ubiquitin conjugation to UBC13/UBE2N and proteasome activity by S-nitrosation.

Bailey J. et al, (2018), Sci Rep, 8

A Requirement for Zic2 in the Regulation of Nodal Expression Underlies the Establishment of Left-Sided Identity.

Dykes IM. et al, (2018), Sci Rep, 8

Genetically engineered two-warhead evasins provide a method to achieve precision targeting of disease-relevant chemokine subsets.

Alenazi Y. et al, (2018), Sci Rep, 8

The N-terminal domain of a tick evasin is critical for chemokine binding and neutralization and confers specific binding activity to other evasins.

Eaton JRO. et al, (2018), J Biol Chem, 293, 6134 - 6146

Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities.

Singh K. et al, (2017), Sci Rep, 7

Pcsk5 is required in the early cranio-cardiac mesoderm for heart development.

Szumska D. et al, (2017), BMC Dev Biol, 17

The Retinoid Agonist Tazarotene Promotes Angiogenesis and Wound Healing.

Al Haj Zen A. et al, (2016), Mol Ther, 24, 1745 - 1759

Distinct genetic architectures for syndromic and nonsyndromic congenital heart defects identified by exome sequencing.

Sifrim A. et al, (2016), Nat Genet, 48, 1060 - 1065

Functional analysis of AEBP2, a PRC2 Polycomb protein, reveals a Trithorax phenotype in embryonic development and in ESCs.

Grijzenhout A. et al, (2016), Development, 143, 2716 - 2723

Negative autoregulation of BMP dependent transcription by SIN3B splicing reveals a role for RBM39.

Faherty N. et al, (2016), Sci Rep, 6

A genome-wide association study of congenital cardiovascular left-sided lesions shows association with a locus on chromosome 20.

Hanchard NA. et al, (2016), Hum Mol Genet, 25, 2331 - 2341

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

Boldt K. et al, (2016), Nat Commun, 7

Exome sequencing identifies rare variants in multiple genes in atrioventricular septal defect.

D'Alessandro LCA. et al, (2016), Genet Med, 18, 189 - 198

Targeted Next-Generation Sequencing Analysis of 1,000 Individuals with Intellectual Disability.

Grozeva D. et al, (2015), Hum Mutat, 36, 1197 - 1204

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