Publications — Radcliffe Department of Medicine

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Mechanical Forces and Their Effect on the Ribosome and Protein Translation Machinery.

Simpson LJ. et al, (2020), Cells, 9

The guidance receptor plexin D1 is a mechanosensor in endothelial cells.

Mehta V. et al, (2020), Nature, 578, 290 - 295

Mechanical Regulation of Protein Translation in the Cardiovascular System.

Simpson LJ. et al, (2020), Front Cell Dev Biol, 8

Role of aminoacyl tRNA syntheses in infectious diseases

READER J., (2019)

Haemodynamics Regulate Fibronectin Assembly via PECAM.

Chen Z. et al, (2017), Sci Rep, 7

Structural characterization of antibiotic self-immunity tRNA synthetase in plant tumour biocontrol agent

Chopra S. et al, (2016), Nature Communications, 7

A Pyranose-2-Phosphate Motif Is Responsible for Both Antibiotic Import and Quorum-Sensing Regulation in Agrobacterium tumefaciens

El Sahili A. et al, (2015), PLOS Pathogens, 11, e1005071 - e1005071

tRNAs as Antibiotic Targets

Chopra S. and Reader J., (2014), International Journal of Molecular Sciences, 16, 321 - 349

Haemodynamic and extracellular matrix cues regulate the mechanical phenotype and stiffness of aortic endothelial cells.

Collins C. et al, (2014), Nat Commun, 5

Natural aminoacyl tRNA synthetase fragment enhances cardiac function after myocardial infarction.

McCormick ME. et al, (2014), PLoS One, 9

Plant tumour biocontrol agent employs a tRNA-dependent mechanism to inhibit leucyl-tRNA synthetase.

Chopra S. et al, (2013), Nat Commun, 4

The mechanism of microcin C resistance provided by the MccF peptidase.

Tikhonov A. et al, (2010), J Biol Chem, 285, 37944 - 37952

Mammalian aminoacyl-tRNA synthetases: cell signaling functions of the protein translation machinery.

Brown MV. et al, (2010), Vascul Pharmacol, 52, 21 - 26

The novel fragment of tyrosyl tRNA synthetase, mini-TyrRS, is secreted to induce an angiogenic response in endothelial cells.

Greenberg Y. et al, (2008), FASEB J, 22, 1597 - 1605

Erratum: VE-cadherin links tRNA synthetase cytokine to antiangiogenic function (Journal of Biological Chemistry (2005) 280 (2405-2408))

Tzima E. et al, (2007), Journal of Biological Chemistry, 282

VE-cadherin links tRNA synthetase cytokine to antiangiogenic function (vol 280, pg 2405, 2005)

Tzima E. et al, (2007), JOURNAL OF BIOLOGICAL CHEMISTRY, 282, 29068 - 29068

Rhizosphere wars: A tale of three plasmids.

Farrand SK. et al, (2007), PLASMID, 57, 214 - 214

Bases of biocontrol: sequence predicts synthesis and mode of action of agrocin 84, the Trojan horse antibiotic that controls crown gall.

Kim J-G. et al, (2006), Proc Natl Acad Sci U S A, 103, 8846 - 8851

Major biocontrol of plant tumors targets tRNA synthetase.

Reader JS. et al, (2005), Science, 309

From cyclohydrolase to oxidoreductase: discovery of nitrile reductase activity in a common fold.

Van Lanen SG. et al, (2005), Proc Natl Acad Sci U S A, 102, 4264 - 4269

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