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The molecular and functional characterization of single cells at scale has emerged as a key driver to unravel tissue biology. Thus, it is important to understand the strengths and limitations of transcriptomic approaches, molecular barcoding and functional assays used to study cellular properties at the single-cell level. Here, we review recent relevant work from the haematopoietic system and discuss how to interpret and integrate data obtained with different technologies.

Original publication




Journal article


Nat Cell Biol

Publication Date





2 - 8


Animals, Cell Differentiation, Cell Lineage, Gene Expression Profiling, Hematopoiesis, Hematopoietic Stem Cells, Humans, Reproducibility of Results, Single-Cell Analysis