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Dynamic interactions between hematopoietic cells and their specialized bone marrow microenvironments, namely the vascular and osteoblastic 'niches', regulate hematopoiesis. The vascular niche is conducive for thrombopoiesis and megakaryocytes may, in turn, regulate the vascular niche, especially in supporting vascular and hematopoietic regeneration following irradiation or chemotherapy. A role for platelets in tumor growth and metastasis is well established and, more recently, the vascular niche has also been implicated as an area for preferential homing and engraftment of malignant cells. This article aims to provide an overview of the dynamic interactions between cellular and molecular components of the bone marrow vascular niche and the potential role of megakaryocytes in bone marrow malignancy.

Original publication

DOI

10.1111/j.1538-7836.2011.04571.x

Type

Journal article

Journal

J Thromb Haemost

Publication Date

02/2012

Volume

10

Pages

177 - 188

Keywords

Animals, Blood Platelets, Bone Marrow Neoplasms, Cell Communication, Endothelial Cells, Hematopoietic Stem Cells, Humans, Megakaryocytes, Neoplasm Invasiveness, Osteoblasts, Signal Transduction, Stem Cell Niche, Stromal Cells