Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Tissue engineering opens multiple opportunities in regenerative medicine, drug testing, and modeling of the hematopoiesis in health and disease. Recapitulating the organization of physiological microenvironments supporting leukocyte development is essential to model faithfully the development of immune cells. Hematopoietic organs are shaped by spatially organized niches defined by multiple cellular contributions. A shared feature of immune niches is the presence of mesenchymal stromal cells endowed with unique roles in organizing niche development, maintenance, and function. Here, we review challenges and opportunities in harnessing stromal cells for the engineering of artificial immune niches and hematopoietic organoids recapitulating leukocyte ontogeny both in vitro and in vivo.

Original publication

DOI

10.3389/fimmu.2021.631279

Type

Journal article

Journal

Front Immunol

Publication Date

2021

Volume

12

Keywords

3D culture, bone marrow niche, hematopoiesis, mesenchymal stroma cell, organoids model, thymus epithelial cell, Animals, Bone Marrow Cells, Humans, Mesenchymal Stem Cells, Mice, Stem Cell Niche, Stromal Cells, Tissue Engineering