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Type 2 diabetes (T2DM) is not only a disorder of impaired insulin secretion but also glucagon oversecretion. However, the link between the two remains unclear. Is it possible that the latter is a consequence of the former? In this issue, Kawamori et al. (2009) have addressed this question by generating alpha cell-specific insulin receptor knockout mice.

Original publication

DOI

10.1016/j.cmet.2009.03.008

Type

Journal article

Journal

Cell Metab

Publication Date

04/2009

Volume

9

Pages

303 - 305

Keywords

Animals, Glucagon, Glucagon-Secreting Cells, Insulin, Insulin-Secreting Cells, Mice, Organ Specificity, Receptor, Insulin, Signal Transduction