PhD, MSc, BSc (Hons)
As a postdoctoral scientist in Professor Robin Choudhury's Group and a Fulford Junior Research Fellow at Somerville College I work on the role of extracellular vesicles in inflammation.
Cells within our body can transcribe, package and deliver messages to other cells, through the generation of nano-sized bubble-shaped envelopes, called extracellular vesicles (EV). Within their enclosed spheres, these messages contain potent instructions that can alter the behaviour and intended biological function of its recipients, which include the very motile and sensitive cells of the immune system. I am uncovering how these shielded messages provoke the immune system into action after a heart attack. Immune system activation after a heart attack directly contributes to further injury and this in turn impacts patient health and well-being.
Exacerbation of Acute Traumatic Brain Injury by Circulating Extracellular Vesicles.
Hazelton I. et al, (2018), J Neurotrauma, 35, 639 - 651
Extracellular vesicles released following heat stress induce bystander effect in unstressed populations
Bewicke-Copley F. et al, (2017), Journal of Extracellular Vesicles, 6
Endothelium-derived extracellular vesicles promote splenic monocyte mobilization in myocardial infarction.
Akbar N. et al, (2017), JCI Insight, 2
Circulating endothelial cell-derived extracellular vesicles mediate the acute phase response and sickness behaviour associated with CNS inflammation.
Couch Y. et al, (2017), Sci Rep, 7
Inflammatory Stroke Extracellular Vesicles Induce Macrophage Activation.
Couch Y. et al, (2017), Stroke, 48, 2292 - 2296