Matt Neville
DPhil
Oxford Biobank Scientific Coordinator
I am the Oxford Biobank and Bioresource Scientific Coordinator, primarily responsible for curation of the Oxford Biobank (OBB) genetic resource and facilitator of Bioresource recruit-by-genotype and recruit-by-phenotype translational research studies available to the Metabolic Research Group (MRG), the larger research community and Industry. My primary research interests focus on understanding the genetic determinants of body fat function and distribution and how this may impact, and be utilised to improve, the health consequences of obesity. Other duties include primary genetic data interrogator and analyst for the MRG, DPhil student supervisor, Lecturer and dissertation supervisor on the Experimental and Translational Therapeutics MSc program and Chair of the senior academic faculty for the OCDEM building.
I completed my DPhil in 2000 in human molecular genetics (Ox) followed by 2 years of R&D in industry (TWT, Madison, Wisconsin, US) working on marketable novel genetic assay systems. Previous research has included the contribution of genetics to smoking addiction and cessation within the General Practice Research group (Ox) and collaborations within the Department of Gastroenterology (Ox), imputing extended HLA haplotypes for association studies with autoimmune diseases such as Irritable Bowel Disease and Behçet's disease. In 2003 I took on a Postdoctoral Researcher position with Prof Fredrik Karpe investigating the genetics of Adipose tissue function and the adverse consequences of Obesity and Type II Diabetes. As a progression from his previous roles within the MRG and the Oxford Biobank I then took on the BRC funded position of Oxford Biobank and Bioresource Scientific Coordinator in 2012.
Recent publications
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The Arg82Cys Polymorphism of the Protein Nepmucin Implies a Role in HDL Metabolism.
Journal article
Metz S. et al, (2022), J Endocr Soc, 6
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Apolipoprotein A-V is a potential target for treating coronary artery disease: evidence from genetic and metabolomic analyses.
Journal article
Ibi D. et al, (2022), J Lipid Res
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The associations between body fat distribution and bone mineral density in the Oxford Biobank: a cross sectional study.
Journal article
Hilton C. et al, (2021), Expert Rev Endocrinol Metab, 1 - 7
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Higher thyrotropin leads to unfavorable lipid profile and somewhat higher cardiovascular disease risk: evidence from multi-cohort Mendelian randomization and metabolomic profiling.
Journal article
van Vliet NA. et al, (2021), BMC Med, 19
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The trans-ancestral genomic architecture of glycemic traits.
Journal article
Chen J. et al, (2021), Nat Genet, 53, 840 - 860
ORCID
0000-0002-6004-5433