Professor of Haematology
- Consultant Haematologist
Erythropoiesis / Regulatory T cells in Bone Marrow Transplantation / Malaria Pathogenesis
The current projects in immuno-haematology have been built on our expertise in the study of host-pathogen interactions in malaria by functional and genetic approaches. The unique virulence of falciparum malaria among the species of human parasites appears to be related to the ability of the parasitised erythrocytes to adhere to specific molecules expressed on vascular endothelium. There has therefore been considerable interest in defining the cellular and molecular adhesive phenotypes of malaria infected erythrocytes. In particular it has been suggested that some adhesive phenotypes may be associated with certain syndromes of severe disease for example coma or cerebral malaria. Until recently it has been thought that sequestration of infected erythrocytes in the peripheral circulation enabled these cells to simply avoid passage through and destruction in the spleen. We have studied the functional and pathological significance of the adhesive phenotypes of malaria infected erythrocytes.
A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis
Bell S. et al, (2021), Communications Biology, 4
Effects of SARS-CoV-2 strain variation on virus neutralisation titres: therapeutic use of convalescent plasma.
Nguyen D. et al, (2021), J Infect Dis
Hyperimmune immunoglobulin for people with COVID-19
Kimber C. et al, (2021), Cochrane Database of Systematic Reviews, 2021
Controlled human malaria infection with a clone of Plasmodium vivax with high quality genome assembly.
Minassian AM. et al, (2021), JCI Insight
Effect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial.
Writing Committee for the REMAP-CAP Investigators None. et al, (2021), JAMA