Professor of Haematology
- Consultant Haematologist
Erythropoiesis / Regulatory T cells in Bone Marrow Transplantation / Malaria Pathogenesis
The current projects in immuno-haematology have been built on our expertise in the study of host-pathogen interactions in malaria by functional and genetic approaches. The unique virulence of falciparum malaria among the species of human parasites appears to be related to the ability of the parasitised erythrocytes to adhere to specific molecules expressed on vascular endothelium. There has therefore been considerable interest in defining the cellular and molecular adhesive phenotypes of malaria infected erythrocytes. In particular it has been suggested that some adhesive phenotypes may be associated with certain syndromes of severe disease for example coma or cerebral malaria. Until recently it has been thought that sequestration of infected erythrocytes in the peripheral circulation enabled these cells to simply avoid passage through and destruction in the spleen. We have studied the functional and pathological significance of the adhesive phenotypes of malaria infected erythrocytes.
A difficult year… so keep on keeping on.
Roberts DJ., (2022), Transfus Med, 32, 443 - 444
Genetically personalised organ-specific metabolic models in health and disease.
Foguet C. et al, (2022), Nat Commun, 13
Systematic Mendelian randomization using the human plasma proteome to discover potential therapeutic targets for stroke.
Chen L. et al, (2022), Nat Commun, 13
Coronavirus disease 2019 subphenotypes and differential treatment response to convalescent plasma in critically ill adults: secondary analyses of a randomized clinical trial.
Fish M. et al, (2022), Intensive Care Med
No widespread dissemination of Chlamydia trachomatis diagnostic-escape variants and the impact of Neisseria gonorrhoeae positivity on the Aptima Combo 2 assay.
Cole MJ. et al, (2022), Sex Transm Infect, 98, 366 - 370