Professor of Haematology
- Consultant Haematologist
Erythropoiesis / Regulatory T cells in Bone Marrow Transplantation / Malaria Pathogenesis
The current projects in immuno-haematology have been built on our expertise in the study of host-pathogen interactions in malaria by functional and genetic approaches. The unique virulence of falciparum malaria among the species of human parasites appears to be related to the ability of the parasitised erythrocytes to adhere to specific molecules expressed on vascular endothelium. There has therefore been considerable interest in defining the cellular and molecular adhesive phenotypes of malaria infected erythrocytes. In particular it has been suggested that some adhesive phenotypes may be associated with certain syndromes of severe disease for example coma or cerebral malaria. Until recently it has been thought that sequestration of infected erythrocytes in the peripheral circulation enabled these cells to simply avoid passage through and destruction in the spleen. We have studied the functional and pathological significance of the adhesive phenotypes of malaria infected erythrocytes.
Measuring the resting naive sub-population of T-regulatory cells improves prediction of suppressive function of clinical grade T-regulatory products.
Lamikanra AA. et al, (2017), Cytotherapy, 19, 440 - 443
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
Astle WJ. et al, (2016), Cell, 167, 1415 - 1429.e19
Distinct gene expression program dynamics during erythropoiesis from human induced pluripotent stem cells compared with adult and cord blood progenitors.
Merryweather-Clarke AT. et al, (2016), BMC Genomics, 17
Roberts DJ. and Weatherall DJ., (2016), Hematol Oncol Clin North Am, 30, xiii - xiv
Hematologic Changes Associated with Specific Infections in the Tropics.
Roberts DJ., (2016), Hematol Oncol Clin North Am, 30, 395 - 415