Contact information
Colleges
David Roberts
FMedSci
Professor of Haematology
- Consultant Haematologist
Erythropoiesis / Regulatory T cells in Bone Marrow Transplantation / Malaria Pathogenesis
The current projects in immuno-haematology have been built on our expertise in the study of host-pathogen interactions in malaria by functional and genetic approaches. The unique virulence of falciparum malaria among the species of human parasites appears to be related to the ability of the parasitised erythrocytes to adhere to specific molecules expressed on vascular endothelium. There has therefore been considerable interest in defining the cellular and molecular adhesive phenotypes of malaria infected erythrocytes. In particular it has been suggested that some adhesive phenotypes may be associated with certain syndromes of severe disease for example coma or cerebral malaria. Until recently it has been thought that sequestration of infected erythrocytes in the peripheral circulation enabled these cells to simply avoid passage through and destruction in the spleen. We have studied the functional and pathological significance of the adhesive phenotypes of malaria infected erythrocytes.
Recent publications
-
Blood transfusion in the Caribbean: Historical perspective in the context of Trinidad and Tobago.
Journal article
Charles KS. et al, (2024), Transfus Med
-
Whole Blood Donor Iron Management Across Europe: Experiences and Challenges in Four Blood Establishments.
Journal article
van den Hurk K. et al, (2024), Transfus Med Rev, 38
-
Changes in Phenotypic and Molecular Features of Naïve and Central Memory T Helper Cell Subsets following SARS-CoV-2 Vaccination.
Journal article
Mosavie M. et al, (2024), Vaccines (Basel), 12
-
Transfusion-induced HLA sensitization in wait-list patients and kidney transplant recipients.
Journal article
Willicombe M. and Roberts DJ., (2024), Kidney Int
-
Misexpression of inactive genes in whole blood is associated with nearby rare structural variants.
Journal article
Vanderstichele T. et al, (2024), Am J Hum Genet, 111, 1524 - 1543