Contact information
Research groups
David Kerr
CBE FMedSci FRCP
Professor of Cancer Medicine
- Consultant Physician
Genetics and Genomics
In collaboration with Dr Rachel Midgley, Oncology Clinical Trials Office, we have conducted a series of international adjuvant trials of chemotherapy for colorectal cancer. In parallel, we have established a biorepository of tissue and constitutional DNA (n=3500) which has allowed us to collaborate with Ian Tomlinson to generate a number of cancer susceptibility SNPs and commercial partners to characterise a prognostic mRNA signature which assists in selection of patients for chemotherapy. We are currently developing biomarkers for the anti-angiogenic agent bevacizumab.
Key publications
djuvant capecitabine plus bevacizumab versus capecitabine alone in patients with colorectal cancer (QUASAR 2): an open-label, randomised phase 3 trial.
Journal article
Kerr RS. et al, (2016), Lancet Oncol, 17, 1543 - 1557
Recent publications
pplicability of mitotic figure counting by deep learning: a development and pan-cancer validation study.
Journal article
Kalsnes J. et al, (2026), FEBS Open Bio
Targeting TFAP2β condensation suppresses the development of esophageal squamous cell carcinoma.
Journal article
Deng Z. et al, (2026), Cell, 189, 887 - 905.e25
Psychiatric disorders associated with increased risk of colorectal cancer in the UK biobank cohort.
Journal article
Wang Z. et al, (2026), Sci Rep, 16
Early-stage lung adenocarcinoma affects DNA methylation and gene expression in adjacent tissues.
Journal article
Wu Y. et al, (2025), EMBO Rep, 26, 5931 - 5958
