Contact information
Research groups
David Kerr
CBE FMedSci FRCP
Professor of Cancer Medicine
- Consultant Physician
Genetics and Genomics
In collaboration with Dr Rachel Midgley, Oncology Clinical Trials Office, we have conducted a series of international adjuvant trials of chemotherapy for colorectal cancer. In parallel, we have established a biorepository of tissue and constitutional DNA (n=3500) which has allowed us to collaborate with Ian Tomlinson to generate a number of cancer susceptibility SNPs and commercial partners to characterise a prognostic mRNA signature which assists in selection of patients for chemotherapy. We are currently developing biomarkers for the anti-angiogenic agent bevacizumab.
Key publications
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Adjuvant capecitabine plus bevacizumab versus capecitabine alone in patients with colorectal cancer (QUASAR 2): an open-label, randomised phase 3 trial.
Journal article
Kerr RS. et al, (2016), Lancet Oncol, 17, 1543 - 1557
Recent publications
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CXD101 and nivolumab in patients with metastatic microsatellite-stable colorectal cancer (CAROSELL): a multicentre, open-label, single-arm, phase II trial.
Journal article
Saunders MP. et al, (2022), ESMO Open, 7
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A clinical decision support system optimising adjuvant chemotherapy for colorectal cancers by integrating deep learning and pathological staging markers: a development and validation study.
Journal article
Kleppe A. et al, (2022), Lancet Oncol
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The UK benefits from a truly National Health Service.
Journal article
Barnes E. et al, (2022), Lancet
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Cancer in sub-Saharan Africa: a Lancet Oncology Commission.
Journal article
Ngwa W. et al, (2022), Lancet Oncol
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The Influence of Activin on the Tumor Microenvironment in Colon Cancer Metastasis.
Journal article
Wiley MB. et al, (2022), FASEB J, 36 Suppl 1