BSc (Hons), MSc, PhD
My research focuses on the changes in calcium handling and contractility that occur in inherited cardiomyopathies. I study mutations in thin filament proteins that cause hypertrophic (HCM) and dilated (DCM) cardiomyopathy. My work has developed myofilament specific genetically encoded calcium sensors for the study of subcellular calcium dynamics in cardiomyocytes expressing HCM and DCM mutations.
My current research is on the development of novel synthesised analogues of epigallocatechin-3-gallate (EGCG), which decrease calcium sensitivity in cardiomyocytes. The aim of which is to provide a safe and effective treatment for patients with HCM.
I also work on developing human induced pluripotent stem cell derived cardiomyocytes as a cellular model when investigating inherited cardiomyopathies. Current induced pluripotent stem cell derived cardiomyocytes more closely resemble embryonic rather than adult cardiomyocytes. I am developing maturation protocols to produce an improved human cellular model to study inherited cardiomyopathies.
I completed my PhD at the University of Nottingham in developmental biology where I studied the role of LIM kinase and metanephric mesenchymal cell migration in the developing kidney.
Measurement of Myofilament-Localized Calcium Dynamics in Adult Cardiomyocytes and the Effect of Hypertrophic Cardiomyopathy Mutations.
Sparrow AJ. et al, (2019), Circ Res, 124, 1228 - 1239
Hypertrophic cardiomyopathy mutations increase myofilament Ca2+ buffering, alter intracellular Ca2+ handling, and stimulate Ca2+-dependent signaling.
Robinson P. et al, (2018), J Biol Chem, 293, 10487 - 10499
LIM kinase function and renal growth: Potential role for LIM kinases in fetal programming of kidney development.
Sparrow AJ. et al, (2017), Life Sci, 186, 17 - 24
Acetylsalicylic acid interferes with embryonic kidney growth and development by a prostaglandin-independent mechanism.
Welham SJM. et al, (2017), World J Nephrol, 6, 21 - 28
Excess maternal salt intake produces sex-specific hypertension in offspring: putative roles for kidney and gastrointestinal sodium handling.
Gray C. et al, (2013), PLoS One, 8